Metal-organic framework derived carbon-based sensor for monitoring of the oxidative stress of living cell and assessment of antioxidant activity of food extracts.

A novel non-enzymatic superoxide anion radical (O) sensor was prepared by silver nanoparticles (AgNPs) decorated organic frameworks (MOFs) compound-derived metal oxide coated carbon material. Transmission electron microscopy (TEM) was employed to characterize morphologies and structures of the as-prepared samples AgNPs/CoO@C. Electrochemical studies indicated that the AgNPs/CoO@C/GCE exhibited excellent detection ability to O. It offered a linear range of 8 orders of magnitude and a super low detection limits of 0.0564 pM. The sensor was successfully adapted to detection of O released from living cells. Furthermore, the capacities of scavenging O of food antioxidants were also studied by electrochemical method at cellular milieu. Accordingly, this work provided tremendous potential for reduction incidence of oxidative stress by intaking food antioxidants.