Ciraru-Vigneron N, Engelman P, Bercau G, Sauvanet E, Bitton C
Service de Gynécologie-Obstétrique, Hôpital Lariboisière, Université Paris VII.
Rev Fr Gynecol Obstet. 1988 Nov;83(11):737-40.
The advantage of antibiotic prophylaxis using a single dose of 2 g of cefotetan, administered during the induction of anesthesia, was studied in 71 patients undergoing an abdominal hysterectomy and presenting at least one of the following risk factors: obesity or procedure exceeding two hours. After random selection, 33 patients were treated, 38 were not and constitute the reference group. Comparison between the two groups shows a significant difference concerning the general morbidity, post-operative fever, urinary infection and abdominal wall abscess. Considering the excellent tolerance of the treatment and the fact that it is easy to use and inexpensive, antibiotic prophylaxis with cefotetan is quite interesting for this type of surgery.
在71例接受腹部子宫切除术且存在以下至少一项危险因素的患者中，研究了在麻醉诱导期使用单剂量2克头孢替坦进行抗生素预防的优势：肥胖或手术时间超过两小时。随机选择后，33例患者接受治疗，38例未接受治疗，构成参考组。两组之间的比较显示，在总体发病率、术后发热、尿路感染和腹壁脓肿方面存在显著差异。考虑到该治疗耐受性良好，且易于使用且成本低廉，头孢替坦进行抗生素预防对于此类手术非常有意义。
