A Clinical Trial on Oral Infection of Preschool Children.

GOALS

Over the past twenty years, the existence of oral () infection has been controversial and is still disputed. It proposes that living H. pylori do not exist in the oral cavity. However, the progressive loss of efficacy of standard eradication therapies has made the treatment of more challenging than ever due to oral infection. We conducted a study to explore the existence of oral infection in preschool children.

PROCEDURES

A total of 178 children were recruited and evaluated using the saliva antigen test (HPS) and the urea breath test (UBT C) to diagnose oral and stomach infections, respectively. The treatments of oral infection included toothpaste only, and toothpaste combined with mouth washing morning and night daily for two months. Group A: Children live with parents who have a stomach disease history. Group B: Children live with parents who have no stomach disease history. Group C: Children with toothpaste treatment. Group D: Children with combined toothpaste and mouth rinse treatments. Group E: Control group with no treatments.

RESULTS

The positive rate of HPS and C were 76.4% and 15.73% in the 95% confidence interval (95% CI) range, respectively, among the 178 children. The positive rate of HPS was significantly higher (<0.001) with the parents who suffered from stomach infections which had been diagnosed by C. After two-month treatments, Group D and Group E provided 26.87% and 26.44% (95% CI) range efficient rates of the oral infection, respectively. The difference between the C, D, and E groups was significant (<0.001).

CONCLUSION

Oral exists in the oral cavity of preschool children. The positive rate of HPS was higher with parents suffering from stomach disease, and treatment was effective in reducing oral infection.