Xu Yuee, Song Yuan, Wang XianPing, Gao Xin, Li ShuXiang, Yee John Kc
SuZhou Municipal Hospital of NanJing Medical University, SuZhou, China.
Research Lab of Oral H. pylori, Everett, WA, USA
Ann Clin Lab Sci. 2018 Nov;48(6):751-756.
Over the past twenty years, the existence of oral () infection has been controversial and is still disputed. It proposes that living H. pylori do not exist in the oral cavity. However, the progressive loss of efficacy of standard eradication therapies has made the treatment of more challenging than ever due to oral infection. We conducted a study to explore the existence of oral infection in preschool children.
A total of 178 children were recruited and evaluated using the saliva antigen test (HPS) and the urea breath test (UBT C) to diagnose oral and stomach infections, respectively. The treatments of oral infection included toothpaste only, and toothpaste combined with mouth washing morning and night daily for two months. Group A: Children live with parents who have a stomach disease history. Group B: Children live with parents who have no stomach disease history. Group C: Children with toothpaste treatment. Group D: Children with combined toothpaste and mouth rinse treatments. Group E: Control group with no treatments.
The positive rate of HPS and C were 76.4% and 15.73% in the 95% confidence interval (95% CI) range, respectively, among the 178 children. The positive rate of HPS was significantly higher (<0.001) with the parents who suffered from stomach infections which had been diagnosed by C. After two-month treatments, Group D and Group E provided 26.87% and 26.44% (95% CI) range efficient rates of the oral infection, respectively. The difference between the C, D, and E groups was significant (<0.001).
Oral exists in the oral cavity of preschool children. The positive rate of HPS was higher with parents suffering from stomach disease, and treatment was effective in reducing oral infection.
在过去二十年里，口腔幽门螺杆菌感染的存在一直存在争议且仍有争论。有人提出口腔中不存在活的幽门螺杆菌。然而，由于口腔幽门螺杆菌感染，标准根除疗法疗效的逐渐丧失使得幽门螺杆菌的治疗比以往任何时候都更具挑战性。我们进行了一项研究以探索学龄前儿童口腔幽门螺杆菌感染的存在情况。
共招募了178名儿童，并分别使用唾液幽门螺杆菌抗原检测（HPS）和尿素呼气试验（UBT C）来诊断口腔和胃部幽门螺杆菌感染。口腔幽门螺杆菌感染的治疗方法包括仅使用牙膏，以及每天早晚使用牙膏并结合漱口，持续两个月。A组：与有胃病病史的父母生活在一起的儿童。B组：与没有胃病病史的父母生活在一起的儿童。C组：接受牙膏治疗的儿童。D组：接受牙膏和漱口水联合治疗的儿童。E组：未接受治疗的对照组。
在178名儿童中，HPS和UBT C的阳性率分别在95%置信区间（95%CI）范围内为76.4%和15.73%。经UBT C诊断患有胃部幽门螺杆菌感染的父母所生儿童的HPS阳性率显著更高（<0.001）。经过两个月的治疗，D组和E组口腔幽门螺杆菌感染的有效率分别为26.87%和26.44%（95%CI）范围。C、D和E组之间的差异显著（<0.001）。
学龄前儿童口腔中存在幽门螺杆菌。有胃病的父母所生儿童的HPS阳性率更高，治疗对减少口腔感染有效。
