Out T A, Kallenberg C G, van Munster P J
Laboratorium voor Experimentele en Klinische immunologie, Amsterdam.
Tijdschr Kindergeneeskd. 1988 Oct;56(5):192-6.
The diagnosis of an immunodeficiency is made after detailed clinical and laboratory investigations. To guide these investigations the Dutch Working Group on Immunodeficiencies had made a protocol for evaluating the functioning of the immune system of patients. The protocol is based on the report 'Immunodeficiency' from a WHO scientific group. This paper discusses the value of laboratory investigations on the following aspects of the immune system: immunoglobulins and their subclasses, primary and secondary antibody responses in vivo, and the complement system. The evaluation of these components of the defense system can firmly establish possibly occurring severe immunodeficiency states. Some cases of chronic and/or recurrent infections, however, remain enigmas that have to be resolved by future investigations on the interactions of infectious agents with the immune system.
免疫缺陷的诊断是在详细的临床和实验室检查之后做出的。为指导这些检查，荷兰免疫缺陷工作组制定了一项评估患者免疫系统功能的方案。该方案基于世界卫生组织科学小组的报告《免疫缺陷》。本文从以下几个方面探讨了实验室检查对免疫系统的价值：免疫球蛋白及其亚类、体内的初次和二次抗体反应以及补体系统。对防御系统这些组成部分的评估能够明确可能出现的严重免疫缺陷状态。然而，一些慢性和/或复发性感染病例仍然是谜团，有待未来关于感染因子与免疫系统相互作用的研究来解决。
