Dong Hui, Xiao Juan, Zhu Rongping, Liu Binggang, Dong Mingjun, Luo Diteng, Sun Tian, Li Qinghua, Jin Junfei
Laboratory of Hepatobiliary and Pancreatic Surgery, the Affiliated Hospital of Guilin Medical University, Guilin, 541001, Guangxi, P.R. China.
J BUON. 2018 Nov-Dec;23(6):1711-1716.
Serum predictors for early diagnosis of hepatocellular carcinoma (HCC) have been investigated. Sphingosine-1-phosphate (S1P) has been widely reported to promote the survival of many types of cancer cells. However, the potential of serum S1P as a diagnostic marker in HCC has not been well characterized. The aim of this study was to identify the relationship between serum S1P and the risk of HCC.
We retrospectively reviewed serum S1P in 63 HCC patients and 39 normal people. Receiver operating characteristic (ROC) curve analysis was performed to define the cut-off value of S1P in the serum. Chi-square test, t-test and multivariate regression analysis were used to investigate the association between serum S1P and individual clinicopathologic parameters.
S1P showed significantly higher level in healthy subjects (1.372±0.116 μM) than that in patients (1.372±0.116 μM). Serum S1P in HCC patients was positively correlated to globulin (t = -3.122, p=0.003), hepatitis B virus (HBV) DNA copies (x2=4.386, p=0.036) and negatively related to AST (x2=2.870, p=0.09). Besides, part of the amount of serum S1P was negatively correlated to albumin (correlation coefficient (β) = -0.056) and positively correlated to alanine aminotransferase (ALT) (β=0.016) according to the regression analysis.
These results suggested that serum S1P could be used as an auxiliary marker for HCC diagnosis, and used to monitor HBV infection in patients with HCC.
已对用于肝细胞癌（HCC）早期诊断的血清预测指标进行了研究。鞘氨醇-1-磷酸（S1P）已被广泛报道可促进多种类型癌细胞的存活。然而，血清S1P作为HCC诊断标志物的潜力尚未得到充分表征。本研究的目的是确定血清S1P与HCC风险之间的关系。
我们回顾性分析了63例HCC患者和39名正常人的血清S1P。采用受试者工作特征（ROC）曲线分析来确定血清中S1P的临界值。使用卡方检验、t检验和多因素回归分析来研究血清S1P与个体临床病理参数之间的关联。
健康受试者的S1P水平（1.372±0.116μM）显著高于患者（1.372±0.116μM）。HCC患者的血清S1P与球蛋白呈正相关（t = -3.122，p = 0.003）、与乙型肝炎病毒（HBV）DNA拷贝数呈正相关（x2 = 4.386，p = 0.036），与谷草转氨酶呈负相关（x2 = 2.870，p = 0.09）。此外，根据回归分析，血清S1P的部分含量与白蛋白呈负相关（相关系数（β）= -0.056），与谷丙转氨酶呈正相关（β = 0.016）。
这些结果表明，血清S1P可作为HCC诊断 的辅助标志物，并用于监测HCC患者的HBV感染。
