Twitchell Spencer, Karsy Michael, Gozal Yair M, Davidson Christian, Couldwell William T, Brockmeyer Douglas
Departments of1Neurosurgery and.
2Pathology, University of Utah; and.
J Neurosurg Pediatr. 2019 Jan 4;23(4):507-511. doi: 10.3171/2018.10.PEDS18537. Print 2019 Apr 1.
Psammomatoid juvenile ossifying fibroma (PJOF) is an uncommon, benign fibro-osseous tumor. It is a purely surgical disease, and a review of the literature revealed that adjuvant therapies, including chemotherapy and radiation, play a limited role. The authors report the case of a 16-year-old male refugee who presented with a giant sinonasal PJOF with parasellar invasion, after having been unable to undergo earlier surgical treatment. The delay in presentation resulted in a large lesion with bilateral optic nerve compression, blindness, and frontal lobe compression. The patient was surgically treated with a two-stage combined cranial and endoscopic endonasal surgical approach. The delay in treatment and significant neurological compromise, which necessitated a two-stage approach, are unique from previously reported cases of PJOF.
砂粒样幼年性骨化性纤维瘤（PJOF）是一种罕见的良性纤维骨性肿瘤。它是一种单纯的外科疾病，文献回顾显示辅助治疗，包括化疗和放疗，作用有限。作者报告了一例16岁男性难民的病例，该患者因无法早期接受手术治疗，就诊时患有巨大的鼻窦PJOF并侵犯鞍旁，就诊延迟导致出现大的病变，伴有双侧视神经受压、失明和额叶受压。该患者接受了两阶段联合开颅和鼻内镜下鼻内手术治疗。治疗延迟和严重的神经功能损害（这需要两阶段手术方法）与先前报道的PJOF病例不同。
