a Peking University Ninth School of Clinical Medicine , Beijing Shi , China.
b Chinese PLA General Hospital , Beijing Shi , China.
Climacteric. 2019 Aug;22(4):361-369. doi: 10.1080/13697137.2018.1547698. Epub 2019 Jan 7.
This study aimed to test the hearing function and to investigate the effect of estrogen on prestin and MYO7A expression in hair cells of the cochlea in ovariectomized rats. We compared the hearing function systematically in normal female Sprague-Dawley rats and in ovariectomized rats with or without exogenous β-estradiol administration by auditory brainstem response measurements and distortion product otoacoustic emissions. In addition, a correlation analysis between the functional parameters and cochlear histology was carried out. There was a significant auditory threshold shift in the high-frequency range in the ovariectomized rats. Prestin and MYO7A expression was lowered in the cochlea of ovariectomized rats. These effects could be recovered by subcutaneous administration of β-estradiol. Low estrogen levels may lead to reduced expression of prestin and MYO7A in cochlea, leading to a menopause-related hearing loss.
本研究旨在测试听力功能，并研究雌激素对去卵巢大鼠耳蜗毛细胞中 prestin 和 MYO7A 表达的影响。我们通过听性脑干反应测量和畸变产物耳声发射系统比较了正常雌性 Sprague-Dawley 大鼠和去卵巢大鼠以及去卵巢大鼠给予外源性β-雌二醇后的听力功能。此外，还进行了功能参数与耳蜗组织学之间的相关性分析。去卵巢大鼠的高频听力阈值有明显的变化。Prestin 和 MYO7A 在去卵巢大鼠耳蜗中的表达降低。这些影响可以通过皮下给予β-雌二醇来恢复。低雌激素水平可能导致耳蜗 prestin 和 MYO7A 的表达减少，导致与绝经相关的听力损失。
