Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, MA 02113, USA.
Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, MA 02113, USA.
Cell Metab. 2019 Feb 5;29(2):238-240. doi: 10.1016/j.cmet.2018.12.011. Epub 2019 Jan 3.
Cancer cells must adapt to metabolic stress during tumor progression. In this issue of Cell Metabolism, Eichner et al. (2019) report that lung cancer development in genetically engineered mice requires the energy sensor AMP-activated protein kinase (AMPK). Their findings suggest that AMPK-mediated induction of lysosomal function supports cancer cell fitness, particularly during the early stages of tumorigenesis.
癌细胞在肿瘤进展过程中必须适应代谢应激。在本期《细胞代谢》中，Eichner 等人（2019）报告称，遗传工程小鼠的肺癌发展需要能量传感器 AMP 激活的蛋白激酶（AMPK）。他们的发现表明，AMPK 介导的溶酶体功能诱导支持癌细胞适应性，特别是在肿瘤发生的早期阶段。
