使用光学相干断层扫描检测新辅助放化疗后放射性纤维化和残留癌范围的可行性：一项离体研究。
Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study.
作者信息
Jelvehgaran Pouya, Alderliesten Tanja, Georgiou Giota, Meijer Sybren L, Bloemen Paul R, Kodach Liudmila L, van Laarhoven Hanneke W M, van Berge Henegouwen Mark I, Hulshof Maarten C C M, Rasch Coen R N, van Leeuwen Ton G, de Boer Johannes F, de Bruin Martijn, van Herk Marcel
机构信息
Department of Biomedical Engineering and Physics, Amsterdam UMC, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
Department of Radiation Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
出版信息
Biomed Opt Express. 2018 Aug 14;9(9):4196-4216. doi: 10.1364/BOE.9.004196. eCollection 2018 Sep 1.
Treatment of resectable esophageal cancer includes neoadjuvant chemo-radiation therapy (nCRT) followed by esophagectomy in operable patients. High-risk surgery may have been avoided in patients with a pathological complete response (pCR). We investigated the feasibility of optical coherence tomography (OCT) to detect residual cancer and radiation-induced fibrosis in 10 esophageal cancer patients that underwent nCRT followed by esophagectomy. We compared our OCT findings with histopathology. Overall, OCT was able to differentiate between healthy tissue, fibrotic tissue, and residual cancer with a sensitivity and specificity of 79% and 67%, respectively. Hence, OCT has the potential to add to the assessment of a pCR.
可切除食管癌的治疗包括新辅助放化疗（nCRT），然后对可手术患者进行食管切除术。病理完全缓解（pCR）的患者可能避免了高风险手术。我们调查了光学相干断层扫描（OCT）在10例接受nCRT后行食管切除术的食管癌患者中检测残留癌和放射性纤维化的可行性。我们将OCT检查结果与组织病理学结果进行了比较。总体而言，OCT能够区分健康组织、纤维化组织和残留癌，敏感性和特异性分别为79%和67%。因此，OCT有可能辅助评估pCR。
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