Miyoshi Seigo, Hamada Hironobu, Katayama Hitoshi, Hamaguchi Naohiko, Kadowaki Toru, Ito Ryoji, Irifune Kazunori, Miyazaki Tatsuhiko, Higaki Jitsuo
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.
Department of Pathogenomics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.
J Cardiol Cases. 2009 Dec 2;1(2):e120-e123. doi: 10.1016/j.jccase.2009.10.005. eCollection 2010 Apr.
We describe a case of pulmonary tumor thrombotic microangiopathy (PTTM) associated with lung cancer. A 63-year-old woman, who had been treated for lung cancer, was admitted to our hospital because of progressive dyspnea. Chest CT films showed reticular shadows in the middle and left upper lobes, and echocardiography revealed severe pulmonary hypertension. Because drug induced pneumonitis and either pulmonary thromboembolism or pulmonary tumor embolism were suspected, corticosteroid and anti-coagulant therapy were administered. Despite these treatments, she died 50 days after admission. Postmortem examination revealed PTTM associated with lung cancer. PTTM should be considered in cancer patients who show progressive respiratory failure and pulmonary hypertension.
我们描述了一例与肺癌相关的肺肿瘤血栓性微血管病（PTTM）。一名63岁曾接受肺癌治疗的女性因进行性呼吸困难入住我院。胸部CT片显示中肺和左上肺叶有网状阴影，超声心动图显示重度肺动脉高压。由于怀疑药物性肺炎以及肺血栓栓塞或肺肿瘤栓塞，给予了皮质类固醇和抗凝治疗。尽管进行了这些治疗，她在入院50天后死亡。尸检显示为与肺癌相关的PTTM。对于出现进行性呼吸衰竭和肺动脉高压的癌症患者，应考虑PTTM。
