Department of Orthopaedic Surgery, Washington University in Saint Louis, St. Louis, MO, USA.
Department of Biomedical Engineering, Washington University in Saint Louis, St. Louis, MO, USA.
J Bone Miner Res. 2019 Apr;34(4):711-725. doi: 10.1002/jbmr.3648. Epub 2019 Jan 7.
Obesity is generally protective against osteoporosis and bone fracture. However, recent studies indicate that the influence of obesity on the skeleton is complex and can be detrimental. We evaluated the effects of a high-fat, obesogenic diet on the femur and radius of 1100 mice (males and females) from the Large-by-Small advanced intercross line (F generation). At age 5 months, bone morphology was assessed by microCT and mechanical properties by three-point bending. Mice raised on a high-fat diet had modestly greater cortical area, bending stiffness, and strength. Size-independent material properties were unaffected by a high-fat diet, indicating that diet influenced bone quantity but not quality. Bone size and mechanical properties were strongly correlated with body mass. However, the increases in many bone traits per unit increase in body mass were less in high-fat diet mice than low-fat diet mice. Thus, although mice raised on a high-fat diet have, on average, bigger and stronger bones than low-fat-fed mice, a high-fat diet diminished the positive relationship between body mass and bone size and whole-bone strength. The findings support the concept that there are diminishing benefits to skeletal health with increasing obesity. © 2019 American Society for Bone and Mineral Research.
肥胖通常对骨质疏松症和骨折有保护作用。然而，最近的研究表明，肥胖对骨骼的影响是复杂的，可能是有害的。我们评估了高脂肪、肥胖诱导饮食对来自大-小先进互交系（F 代）的 1100 只（雄性和雌性）小鼠股骨和桡骨的影响。在 5 个月大时，通过 microCT 评估骨形态，通过三点弯曲评估机械性能。高脂肪饮食组的小鼠皮质面积、弯曲刚度和强度略有增加。不受高脂肪饮食影响的尺寸独立材料性能表明，饮食影响骨量而不影响骨质量。骨大小和机械性能与体重密切相关。然而，与低脂饮食组相比，高脂肪饮食组每单位体重增加的许多骨特征的增加幅度较小。因此，尽管高脂肪饮食组的小鼠平均拥有比低脂饮食组更大、更强壮的骨骼，但高脂肪饮食会降低体重和骨大小以及整个骨骼强度之间的正相关关系。这些发现支持了这样一种概念，即随着肥胖程度的增加，骨骼健康的益处会逐渐减少。© 2019 美国骨骼与矿物质研究协会。
