Rapamycin - mTOR + BRAF = ? Using relational similarity to find therapeutically relevant drug-gene relationships in unstructured text.
作者信息
Fathiamini Safa, Johnson Amber M, Zeng Jia, Holla Vijaykumar, Sanchez Nora S, Meric-Bernstam Funda, Bernstam Elmer V, Cohen Trevor
机构信息
School of Biomedical Informatics, The University of Texas Health Science Center at Houston, TX, United States.
Sheikh Khalifa Al Nahyan Ben Zayed Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
出版信息
J Biomed Inform. 2019 Feb;90:103094. doi: 10.1016/j.jbi.2019.103094. Epub 2019 Jan 4.
Abstract
摘要
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本文引用的文献
1
Clinical Concept Embeddings Learned from Massive Sources of Multimodal Medical Data.从海量多模态医学数据中学习的临床概念嵌入。
Pac Symp Biocomput. 2020;25:295-306.
2
Probabilistic Prognostic Estimates of Survival in Metastatic Cancer Patients (PPES-Met) Utilizing Free-Text Clinical Narratives.利用自由文本临床记录对转移性癌症患者进行生存概率预测估计（PPES-Met）。
Sci Rep. 2018 Jul 3;8(1):10037. doi: 10.1038/s41598-018-27946-5.
3
Adapting Word Embeddings from Multiple Domains to Symptom Recognition from Psychiatric Notes.将多领域词嵌入应用于精神科病历症状识别
AMIA Jt Summits Transl Sci Proc. 2018 May 18;2017:281-289. eCollection 2018.
4
A global network of biomedical relationships derived from text.从文本中提取的生物医学关系的全球网络。
Bioinformatics. 2018 Aug 1;34(15):2614-2624. doi: 10.1093/bioinformatics/bty114.
5
Embedding of semantic predications.语义谓词的嵌入
J Biomed Inform. 2017 Apr;68:150-166. doi: 10.1016/j.jbi.2017.03.003. Epub 2017 Mar 8.
6
Learning Low-Dimensional Representations of Medical Concepts.学习医学概念的低维表示。
AMIA Jt Summits Transl Sci Proc. 2016 Jul 20;2016:41-50. eCollection 2016.
7
Automated identification of molecular effects of drugs (AIMED).药物分子效应的自动识别（AIMED）
J Am Med Inform Assoc. 2016 Jul;23(4):758-65. doi: 10.1093/jamia/ocw030. Epub 2016 Apr 23.
8
A Study of Neural Word Embeddings for Named Entity Recognition in Clinical Text.用于临床文本中命名实体识别的神经词嵌入研究
AMIA Annu Symp Proc. 2015 Nov 5;2015:1326-33. eCollection 2015.
9
Reasoning with Vectors: A Continuous Model for Fast Robust Inference.向量推理：一种用于快速稳健推理的连续模型。
Log J IGPL. 2015 Oct;23(2):141-173. doi: 10.1093/jigpal/jzu028. Epub 2014 Nov 19.
10
Learning the Structure of Biomedical Relationships from Unstructured Text.从非结构化文本中学习生物医学关系的结构
PLoS Comput Biol. 2015 Jul 28;11(7):e1004216. doi: 10.1371/journal.pcbi.1004216. eCollection 2015 Jul.
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