Vial Nicolas, Vallard Alexis, Jmour Omar, Rehailia-Blanchard Amel, Ben Mrad Majed, Trone Jane-Chloe, Daguenet Elisabeth, Guy Jean-Baptiste, Magné Nicolas
Institut de cancérologie Lucien Neuwirth, département de radiothérapie, 108 bis, avenue Albert-Raimond, BP60008, 42271 Saint-Priest-en-Jarez cedex, France.
Institut de cancérologie Lucien Neuwirth, département de radiothérapie, 108 bis, avenue Albert-Raimond, BP60008, 42271 Saint-Priest-en-Jarez cedex, France.
Bull Cancer. 2019 Jan;106(1):48-54. doi: 10.1016/j.bulcan.2018.12.006. Epub 2019 Jan 4.
Innovation in radiotherapy should meet multiple challenges, both technically, biologically, clinically and socially. Scientific, technological and biological advances have resulted in major changes in the implementation, indications, and therapeutic index of radiotherapy over the last century. Based on technical innovations (conformal radiotherapy, intensity modulation, CBCT, stereotactic body radiotherapy and MRI embedded system) and knowledge in cancer biology ("oxygen effect", "checkpoints", targeted therapies, molecular profiles and immunotherapy) highlighted in recent decades, the news in radiotherapy is rich and varied. The 2018 news are particularly focused in the role of hypofractionation in prostate cancer, the use of stereotactic body radiotherapy in oligometastatic patients, the possibility of de-intensify treatment in HPV-related oropharynx cancer, and the combination of short-term androgen deprivation to prostate bed salvage radiotherapy. The present manuscript reviews the 2018 latest advances.
放射治疗的创新应在技术、生物学、临床和社会等多个方面应对挑战。在过去的一个世纪里，科学、技术和生物学的进步使放射治疗的实施、适应症和治疗指数发生了重大变化。基于近几十年来突出的技术创新（适形放疗、调强放疗、CBCT、立体定向体部放疗和MRI嵌入式系统）以及癌症生物学知识（“氧效应”、“检查点”、靶向治疗、分子图谱和免疫治疗），放射治疗领域的新进展丰富多样。2018年的进展尤其集中在大分割放疗在前列腺癌中的作用、立体定向体部放疗在寡转移患者中的应用、HPV相关口咽癌减量化治疗的可能性以及短期雄激素剥夺与前列腺床挽救性放疗的联合应用。本文综述了2018年的最新进展。
