Dzalilova D Sh, Diatroptova M A, Mkhitarov V A, Diatroptov M E
Research Institute of Human Morphology, Moscow, Russia.
Bull Exp Biol Med. 2019 Jan;166(3):413-416. doi: 10.1007/s10517-019-04362-x. Epub 2019 Jan 8.
Daily dynamics of changes in the latency of a response to dissociative anesthetic tiletamine (time from injection to ataxia) was studied in mature Wistar rats. Both intramuscular and intravenous administration of the anesthetic was associated with 4-day oscillations of the latent period synchronous with the dynamics of changes in the concentration of glucocorticoid hormones. The period and phases of the infradian rhythm of resistance to the anesthetic remained unchanged after removal of both adrenal glands and testes and administration of corticosterone synthesis blocker trilostane diminishing the 4-day cycle of changes in corticosterone level. Therefore, hormones of the adrenal glands and testes do not play the key role in the mechanisms of formation of the 4-day infradian rhythm.
在成年Wistar大鼠中研究了对解离麻醉剂替来他明的反应潜伏期（从注射到共济失调的时间）的每日动态变化。麻醉剂的肌肉注射和静脉注射均与潜伏期的4天振荡有关，该振荡与糖皮质激素浓度的变化动态同步。在摘除肾上腺和睾丸并给予皮质酮合成阻滞剂曲洛司坦后，对麻醉剂抵抗的次昼夜节律的周期和相位保持不变，皮质酮水平的4天变化周期也随之减弱。因此，肾上腺和睾丸的激素在4天次昼夜节律形成机制中不发挥关键作用。
