孕中期糖化血红蛋白水平（HbA1c）及其与口服葡萄糖耐量试验的相关性（世界卫生组织，1999年）
Mid-trimester glycosylated hemoglobin levels (HbA1c) and its correlation with oral glucose tolerance test (World Health Organization 1999).
作者信息
Dubey Devanshi, Kunwar Shipra, Gupta Uma
机构信息
Department of Obstetrics and Gynaecology, Era's Lucknow Medical College and Hospital, Lucknow, India.
Department of Obstetrics and Gynaecology, Mayo Institute of Medical Sciences, Lucknow, India.
出版信息
J Obstet Gynaecol Res. 2019 Apr;45(4):817-823. doi: 10.1111/jog.13916. Epub 2019 Jan 7.
AIM
The aim of the present study was to assess the role of hemoglobin A1c (HbA1c) in screening of gestational diabetes mellitus (GDM) and to compare its efficacy with 75 g oral glucose tolerance test (OGTT) (World Health Organization [WHO]) screening criteria.
METHODS
A prospective observational study was performed on a total of 260 women attending antenatal outpatient department of our hospital at 24-28 weeks of gestation. All women underwent 75-g OGTT testing, and WHO 1999 criteria was used for diagnosis of GDM. Also, a HbA1c test was performed for the same women.
RESULTS
Prevalence of GDM was found to be 19.6% by OGTT. Mean HbA1c values in GDM was significantly higher than non-GDM. HbA1c correlated well with both fasting and 2 h postprandial levels but there was better correlation with 2-h postprandial level.
CONCLUSION
The incidence of gestational diabetes is rising in South-East Asian countries, especially in India. HBA1c could be a potential screening test for GDM.
目的
本研究旨在评估糖化血红蛋白A1c（HbA1c）在妊娠期糖尿病（GDM）筛查中的作用，并将其与75克口服葡萄糖耐量试验（OGTT）（世界卫生组织[WHO]）筛查标准的效果进行比较。
方法
对我院产前门诊24至28周妊娠的260名妇女进行了一项前瞻性观察研究。所有妇女均接受了75克OGTT检测，并采用WHO 1999标准诊断GDM。同时，对这些妇女进行了HbA1c检测。
结果
通过OGTT发现GDM患病率为19.6%。GDM患者的平均HbA1c值显著高于非GDM患者。HbA1c与空腹及餐后2小时血糖水平均有良好相关性，但与餐后2小时血糖水平的相关性更好。
结论
东南亚国家，尤其是印度，妊娠期糖尿病的发病率正在上升。HbA1c可能是GDM的一种潜在筛查试验。
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