Department of Medical Physiology, Faculty of Medicine, Pavol Jozef Safarik University, 040 11 Košice, Slovakia.
Internal and Diabetology Outpatient Department, Human-Care s.r.o., Affiliated Study Foundation for Faculty of Medicine, Pavol Jozef Safarik University, 040 11 Košice, Slovakia.
Int J Environ Res Public Health. 2021 Mar 25;18(7):3402. doi: 10.3390/ijerph18073402.
: The aim of the study was to compare the continuous glucose monitoring (CGM)-determined glycaemic variability (GV) of pregnant women with gestational diabetes mellitus (GDM) and without GDM (CG; control group). The secondary aim was to evaluate the association between risk factors of diabetes in pregnancy and parameters of glyceamic control. : Demographic, biometric and biochemical parameters were obtained for pregnant women (20-38 years old) who after an oral glucose tolerance test were examined by 7-day continuous glucose monitoring using a iPro2 Professional CGM. : The differences in GV between women with GDM and CG compared by total area under glucose curve (total AUC, (mmol·day/L) was statistically significant ( = 0.006). Other parameters of glycaemic control such as mean glucose, standard deviation, coefficient of variation, J-index, % time-above target range 7.8 mmol/L (%TAR), % time-in range 3.5-7.8 mmol/L (%TIR), time-below target range 3.5 mmol/L (%TBR), glycated haemoglobin were not significantly different in the study groups. Risk factors (a family history of diabetes, pre-pregnancy BMI, higher weight gain and age) correlated with parameters of glycaemic control. : We found a significant difference in GV of women with and without GDM by total AUC determined from CGM. TIR metrics were close to significance. Our work points at an increased GV in relation to the risk factors of GDM. Pregnant women with risk factors have higher probability of severe GV with its consequences on maternal and fetal health state.
: 本研究旨在比较妊娠期糖尿病（GDM）和非 GDM（CG；对照组）孕妇的连续血糖监测（CGM）确定的血糖变异性（GV）。次要目的是评估妊娠糖尿病的危险因素与血糖控制参数之间的关系。 : 在口服葡萄糖耐量试验后，对 20-38 岁的孕妇进行了 7 天连续血糖监测，使用 iPro2 Professional CGM 检测了血糖，获得了人口统计学、生物统计学和生物化学参数。 : 与 CG 相比，GDM 孕妇的 GV 差异在总血糖曲线下面积（总 AUC，mmol·天/L）方面具有统计学意义（=0.006）。其他血糖控制参数，如平均血糖、标准差、变异系数、J-指数、7.8mmol/L 以上目标范围时间百分比（%TAR）、3.5-7.8mmol/L 范围内时间百分比（%TIR）、3.5mmol/L 以下目标范围时间百分比（%TBR）、糖化血红蛋白在研究组中无显著差异。危险因素（糖尿病家族史、孕前 BMI、体重增加较多和年龄）与血糖控制参数相关。 : 我们发现 CGM 确定的总 AUC 中 GDM 组和非 GDM 组的 GV 存在显著差异。TIR 指标接近显著。我们的工作表明，与 GDM 的危险因素相关的 GV 增加。有危险因素的孕妇发生严重 GV 的可能性更高，这对母婴健康状态有影响。
