短期输注丙戊酸盐诱发的静止性震颤的消除：一种可逆现象。
Disabling Resting Tremors Induced by the Short-term Infusion of Valproate: A Reversible Phenomenon.
作者信息
Gupta Ashutosh, Kushwaha Suman
机构信息
Department of Neurology, Institute of Human Behavior and Allied Sciences, Delhi, IN.
出版信息
Tremor Other Hyperkinet Mov (N Y). 2018 Dec 8;8:615. doi: 10.7916/D8DV32T3. eCollection 2018.
BACKGROUND
Drug-induced tremors after long-term administration of anti-epileptics have been described in the literature. Such tremors are usually postural or action in nature with infrequent resting nature.
CASE REPORT
A 23-year-old female presented in status epilepticus. Past and family histories were negative for seizures. She was managed per protocol with valproate. Within hours, she developed resting tremors. The tremors subsided on changing the anti-epileptic.
DISCUSSION
Resting tremors have mostly been described in the literature as long-term side-effects of valproate. This case illustrates that even short-term infusion of valproate can cause resting tremors.
背景
长期服用抗癫痫药物后出现药物性震颤在文献中已有描述。此类震颤通常为姿势性或动作性震颤，静止性震颤较少见。
病例报告
一名23岁女性出现癫痫持续状态。既往史和家族史均无癫痫发作。按照方案给予丙戊酸盐治疗。数小时内，她出现了静止性震颤。更换抗癫痫药物后震颤缓解。
讨论
文献中大多将静止性震颤描述为丙戊酸盐的长期副作用。本病例表明，即使短期输注丙戊酸盐也可引起静止性震颤。
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