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一名肾移植受者的慢性进行性播散性组织胞浆菌病

Chronic progressive disseminated histoplasmosis in a renal transplant recipient.

作者信息

Tanveer Farah, Younas Mariam, Johnson Leonard B

机构信息

Division of Infectious Disease, Department of Internal Medicine, St. John Hospital and Medical Center, 19251 Mack Avenue, Suite 340, Detroit 48236, MI, United States of America.

Wayne State University School of Medicine, Detroit 48202, MI, United States of America.

出版信息

Med Mycol Case Rep. 2018 Dec 21;23:53-54. doi: 10.1016/j.mmcr.2018.12.006. eCollection 2019 Mar.

DOI:10.1016/j.mmcr.2018.12.006
PMID:30619685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6313815/
Abstract

Hematopoietic and solid organ transplant recipients are at increased risk of opportunistic infections and infections usually are severe due to impaired cell mediated immunity. We report an unusual case of disseminated histoplasmosis in a renal transplant recipient manifesting with a chronic progressive course over several years. After starting treatment with itraconazole, the patient showed marked improvement in his symptoms and had clinical resolution.

摘要

造血及实体器官移植受者发生机会性感染的风险增加,且由于细胞介导免疫受损,感染通常较为严重。我们报告了一例肾移植受者播散性组织胞浆菌病的罕见病例,该病例表现为数年的慢性进展病程。开始使用伊曲康唑治疗后,患者症状明显改善并获得临床缓解。

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本文引用的文献

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Subacute progressive disseminated histoplasmosis in immunocompetent patient.免疫功能正常患者的亚急性进行性播散性组织胞浆菌病
Korean J Intern Med. 2016 Sep;31(5):999-1002. doi: 10.3904/kjim.2015.069. Epub 2016 Feb 22.
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Disseminated Histoplasmosis in an Immunocompetent Host Presenting as Pancytopenia with Bilateral Adrenal Masses.免疫功能正常宿主中表现为全血细胞减少伴双侧肾上腺肿块的播散性组织胞浆菌病。
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Progressive disseminated histoplasmosis presenting with cachexia and hypercalcemia.进行性播散性组织胞浆菌病,表现为恶病质和高钙血症。
Int J Gen Med. 2013;6:79-83. doi: 10.2147/IJGM.S41520. Epub 2013 Feb 27.
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Histoplasma antigen clearance during treatment of histoplasmosis in patients with AIDS determined by a quantitative antigen enzyme immunoassay.通过定量抗原酶免疫测定法确定艾滋病患者组织胞浆菌病治疗期间组织胞浆菌抗原清除情况。
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Diagnosis of histoplasmosis in immunosuppressed patients.免疫抑制患者组织胞浆菌病的诊断
Curr Opin Infect Dis. 2008 Aug;21(4):421-5. doi: 10.1097/QCO.0b013e328306eb8d.
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Disseminated histoplasmosis in a haemodialysis patient on immunosuppression after graft failure.移植失败后接受免疫抑制治疗的血液透析患者发生播散性组织胞浆菌病。
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Diagnosis of disseminated histoplasmosis by detection of Histoplasma capsulatum antigen in serum and urine specimens.通过检测血清和尿液标本中的荚膜组织胞浆菌抗原诊断播散性组织胞浆菌病。
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