Eliopoulos G M
Department of Medicine, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215.
J Antimicrob Chemother. 1988 Jul;22 Suppl A:37-44. doi: 10.1093/jac/22.supplement_a.37.
Inducible beta-lactamases can significantly affect the activities of both beta-lactamase-stable and beta-lactamase-sensitive antibiotics. beta-Lactam antibiotics vary in their ability to induce beta-lactamases. Strong inducers can antagonize the antimicrobial activity of other beta-lactams.
可诱导β-内酰胺酶可显著影响β-内酰胺酶稳定型抗生素和β-内酰胺酶敏感型抗生素的活性。β-内酰胺类抗生素在诱导β-内酰胺酶的能力方面存在差异。强效诱导剂可拮抗其他β-内酰胺类药物的抗菌活性。
