以TFBen为CO源，钯催化苄胺羰基化合成异吲哚啉酮
Palladium-Catalyzed Carbonylative Synthesis of Isoindolinones from Benzylamines with TFBen as the CO Source.
作者信息
Fu Lu-Yang, Ying Jun, Qi Xinxin, Peng Jin-Bao, Wu Xiao-Feng
机构信息
Department of Chemistry , Zhejiang Sci-Tech University , Xiasha Campus , Hangzhou 310018 , People's Republic of China.
Leibniz-Institut für Katalyse e. V. an der Universität Rostock , Albert-Einstein-Straβe 29a , 18059 Rostock , Germany.
出版信息
J Org Chem. 2019 Feb 1;84(3):1421-1429. doi: 10.1021/acs.joc.8b02862. Epub 2019 Jan 16.
A palladium-catalyzed C-H carbonylation of benzylamines for the synthesis of isoindolinone scaffolds has been developed. This protocol is conducted under gas-free conditions by using benzene-1,3,5-triyl triformate (TFBen) as a convenient CO surrogate, furnishing a variety of isoindolinone derivatives in moderate to high yields (up to 95%).
已开发出一种用于合成异吲哚啉酮骨架的钯催化苄胺C-H羰基化反应。该方案在无气体条件下进行，使用苯-1,3,5-三基三甲酸酯（TFBen）作为方便的CO替代物，以中等到高收率（高达95%）提供各种异吲哚啉酮衍生物。
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