Payraudeau P, Ciaru-Vigneron N, Nguyen Tan Lung R, Sauvanet E, Schermann J M, Guedeney X, Barrier J
Service de Gynécologie-Obstétrique, Hôpital Lariboisière, Paris.
J Gynecol Obstet Biol Reprod (Paris). 1988;17(4):535-41.
In newborns, atrial flutter is a rare, but severe condition. Late diagnosis was usual and based on fetal ECG. Now, fetal ultrasonography can differentiate in utero atrial flutter and other supra ventricular tachycardias; so it can be treated before development of cardiac failure. Among numerous and various available drugs, digoxin is universally recommended, but the delayed effect and the maternal serum levels to obtain effective fetal concentration of digoxin are not well known. Furthermore, endogenous "digoxin-like" substances have been found in maternal blood in late pregnancy; this finding raises the problem of the validity of monitoring the treatment only by serum digoxin levels. A case of atrial flutter, diagnosed in utero by ultrasonography and treated by digoxin before development of cardiac failure is reported. Neonatal echocardiography showed an aneurysm of the atrial septum, which needed simple monitoring. Its responsibility in the pathogenesis of the arrhythmia is unclear. Numerous cases of aneurysm of the atrial septum have been reported in healthy adults without atrial arrhythmias.
在新生儿中,心房扑动是一种罕见但严重的病症。以往通常是基于胎儿心电图进行晚期诊断。如今,胎儿超声检查能够在子宫内鉴别心房扑动与其他室上性心动过速;因此可在心力衰竭发展之前进行治疗。在众多可用药物中,地高辛是普遍推荐使用的,但地高辛产生延迟效应以及达到有效胎儿浓度所需的母体血清水平尚不明确。此外,在妊娠晚期母体血液中发现了内源性“地高辛样”物质;这一发现引发了仅通过血清地高辛水平监测治疗有效性的问题。本文报告了一例经超声检查在子宫内诊断出心房扑动,并在心力衰竭发展之前用地高辛进行治疗的病例。新生儿超声心动图显示房间隔瘤,对此只需进行简单监测。其在心律失常发病机制中的作用尚不清楚。在无心律失常的健康成年人中也有许多房间隔瘤的病例报道。