乳腺侵袭性囊状高分泌性癌：一种罕见的乳腺癌亚型：病例报告及文献复习。
Invasive cystic hypersecretory carcinoma of the breast: a rare variant of breast cancer: a case report and review of the literature.
机构信息
Department of Pathology, Central Hospital affiliated to Shenyang Medical College, No 5, South Seven West Road, Tiexi District, Shenyang, Liaoning, 110024, People's Republic of China.
出版信息
BMC Cancer. 2019 Jan 8;19(1):31. doi: 10.1186/s12885-018-5260-2.
BACKGROUND
Cystic hypersecretory carcinoma is a rare subtype of breast cancer. It is a member of cystic hypersecretory lesions, which include a series of pathological disease lineages: cystic hypersecretory hyperplasia (CHH), CHH with atypia, cystic hypersecretory carcinoma (CHC) and invasive CHC. It was found that most cystic hypersecretion lesions were in situ carcinoma, and only 19 cases of invasive cystic hypersecretion carcinoma were reported.
CASE PRESENTATION
We are reporting a case of a 63-year-old female who had a lump in her left breast for 3 years. A modified radical mastectomy was done and morphological diagnosis of invasive CHC with axillary node metastasis was made.
CONCLUSIONS
Owing to a smaller number of reported cases, little is known about the biological behavior, prognosis and molecular study of cystic hypersecretion lesions. Therefore, more cases with follow-up data are needed to reveal the biological behavior of this rare tumor.
背景
囊泡性高分泌性癌是一种罕见的乳腺癌亚型。它是囊泡性高分泌病变的成员之一，包括一系列病理性疾病谱系：囊泡性高分泌增生（CHH）、伴非典型性的 CHH、囊泡性高分泌癌（CHC）和侵袭性 CHC。研究发现，大多数囊泡性高分泌病变为原位癌，仅有 19 例侵袭性囊泡性高分泌癌的报道。
病例介绍
我们报告了一例 63 岁女性，左侧乳房肿块 3 年。行改良根治性乳房切除术，形态学诊断为腋窝淋巴结转移的侵袭性 CHC。
结论
由于报道的病例较少，对囊泡性高分泌病变的生物学行为、预后和分子研究知之甚少。因此，需要更多有随访数据的病例来揭示这种罕见肿瘤的生物学行为。
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