Lee Ji Shin, Lee Young Jik
Department of Pathology, Seonam University College of Medicine, 720 Kwangchi-dong, Namwon 590-711, Korea.
J Korean Med Sci. 2004 Feb;19(1):149-51. doi: 10.3346/jkms.2004.19.1.149.
Cystic hypersecretory lesions of the breast are rare. These breast lesions include cystic hypersecretory hyperplasia (CHH), atypical CHH, and cystic hypersecretory carcinoma (CHC). The characteristic features are dilated ducts and cysts filled with thyroid colloid-like eosinophilic secretion. Only seven cases of invasive CHC have been reported in the literature. Here, we report an additional case of invasive CHC. The histologic features of the tumor showed both micropapillary intraductal carcinoma and focal high-grade invasive carcinoma in a background of CHH. This case suggests that cystic hypersecretory breast lesions encompass a spectrum of pathologic lesions including CHH, atypical CHH, CHC, and invasive CHC.
乳腺囊性高分泌性病变较为罕见。这些乳腺病变包括囊性高分泌性增生（CHH）、非典型CHH和囊性高分泌性癌（CHC）。其特征性表现为扩张的导管和充满甲状腺胶体样嗜酸性分泌物的囊肿。文献中仅报道过7例浸润性CHC。在此，我们报告1例新增的浸润性CHC病例。肿瘤的组织学特征显示，在CHH背景下既有微乳头导管内癌，又有局灶性高级别浸润性癌。该病例提示，乳腺囊性高分泌性病变涵盖了一系列病理病变，包括CHH、非典型CHH、CHC和浸润性CHC。
