首个与CD4和CCR5受体结合的HIV-1 gp120结构。
The first structure of HIV-1 gp120 with CD4 and CCR5 receptors.
作者信息
Guan Yongjun
机构信息
Antibody BioPharm, Inc, 401 Professional Dr. Ste241, Gaithersburg, MD 20879 USA.
出版信息
Cell Biosci. 2019 Jan 3;9:2. doi: 10.1186/s13578-018-0267-6. eCollection 2019.
Abstract
Shaik et al. recently published online the cryo-electron microscopy structure of HIV-1 gp120 in complex with CD4 and CCR5 receptors. This is the first structure of the ternary HIV-1 gp120/CD4/CCR5 complex. This breakthrough of Env structure provides insights into HIV-1 fusion mechanism, CCR5 function, co-receptor switch, and, most importantly, the development of co-receptor-targeted therapeutic inhibitor and HIV-1 vaccine. It also shed lights on the immunogenicity of gp120 by revealing the stably exposed conserved gp41-interactive region of gp120 in the complex.
摘要
沙伊克等人最近在网上发表了与CD4和CCR5受体结合的HIV-1 gp120的冷冻电子显微镜结构。这是三元HIV-1 gp120/CD4/CCR5复合物的首个结构。Env结构的这一突破为HIV-1融合机制、CCR5功能、共受体转换提供了见解，最重要的是，为共受体靶向治疗抑制剂和HIV-1疫苗的开发提供了见解。它还通过揭示复合物中gp120稳定暴露的保守gp41相互作用区域，阐明了gp120的免疫原性。
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