Milewski C, Dienes H P, Collo D
Hals-Nasen-Ohrenklinik der Universität Mainz.
Laryngol Rhinol Otol (Stuttg). 1988 Aug;67(8):385-8.
30 patients with paraganglioma of the head and neck region were subjected to surgery at the Department of Otorhinolaryngology during 1978-1985. Histological classification of the obtained specimens was performed using also immunocytochemical methods to detect more details. The site of origin of the tumours was the glomus tympanicum in 18 cases, 7 times the glomus caroticum and 5 times the glomus jugulare. Antibodies against neuronal components (S-100 protein), endothelial cells (UEAI) and endocrine activity (NSE) were used for subtyping by PAP-method (Figs. 1-3). Immunocytochemistry provided for an easy subtyping of the tumours and showed an increase in severe progress forms in adenomatous variants of paragangliomas.
1978年至1985年间，30名头颈部副神经节瘤患者在耳鼻喉科接受了手术治疗。对获取的标本进行组织学分类时，还采用了免疫细胞化学方法以检测更多细节。肿瘤的起源部位为鼓室球18例，颈动脉体球7例，颈静脉球5例。采用PAP法，使用针对神经成分（S-100蛋白）、内皮细胞（UEAI）和内分泌活性（NSE）的抗体进行亚型分类（图1-3）。免疫细胞化学有助于肿瘤的简易亚型分类，并显示在副神经节瘤的腺瘤样变体中，严重进展形式有所增加。
