来自[植物名称未给出]的烷基酰胺及其对B16黑色素瘤细胞中黑色素含量和酪氨酸酶活性的刺激作用。
-Alkylamides from L. and their stimulative effects on the melanin content and tyrosinase activity in B16 melanoma cells.
作者信息
Abdubakiev Sardorbek, Li Hongliang, Lu Xueying, Li Jun, Aisa H A
机构信息
The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P. R. China.
University of Chinese Academy of Sciences, Beijing, P. R. China.
出版信息
Nat Prod Res. 2020 Sep;34(17):2510-2513. doi: 10.1080/14786419.2018.1539982. Epub 2019 Jan 9.
L., known as long pepper, is an edible and medicinal plant used as spice and for the treatment of stomach disease and analgesia in traditional Chinese medicine. -Alkylamides are the major secondary metabolites in this plant. Sixteen known -alkylamides were isolated from . Their structures were established on the basis of spectroscopic data and comparison to reported literatures. Among them, five compounds were isolated from this plant for the first time. Ethanol extract, compounds , , , and exhibited potent ability to increase the melanin content and weak stimulative effect on the tyrosinase activity in a concentration-dependent manner. Moreover, compound also presented strong capacity to increase the tyrosinase activity in a concentration-dependent manner. These results indicated that might be a good natural source of lead compound for skin disorder diseases.
荜拔，又称长胡椒，是一种可食用和药用的植物，在传统中医中用作香料，用于治疗胃病和止痛。-烷基酰胺是这种植物中的主要次生代谢产物。从荜拔中分离出16种已知的-烷基酰胺。它们的结构是根据光谱数据并与已报道的文献进行比较而确定的。其中，有5种化合物是首次从该植物中分离出来的。乙醇提取物、化合物、、、和表现出以浓度依赖的方式增加黑色素含量的强大能力以及对酪氨酸酶活性的微弱刺激作用。此外，化合物还表现出以浓度依赖的方式强烈增加酪氨酸酶活性的能力。这些结果表明，荜拔可能是治疗皮肤疾病的先导化合物的良好天然来源。
Zotero 插件