Wadgave Umesh, Khairnar Mahesh R, Kadu Tanvi S, Wadgave Yogesh
a Department of Public Health Dentistry , Bharati Vidyapeeth Deemed University Dental College and Hospital , Sangli , India.
b Bharati Vidyapeeth Deemed University Dental College and Hospital , Sangli , India.
Acta Odontol Scand. 2019 Apr;77(3):181-183. doi: 10.1080/00016357.2018.1522448. Epub 2019 Jan 9.
Significance testing for comparison of the baseline differences between the intervention arms has received a strong condemnation. The goal of this study was to assess the prevalence of randomized controlled trials (RCTs) comparing the baseline characteristics between intervention groups using significance tests in top ten impact factor dental journals.
RCTs published in 10 high impact factor dental journals were searched in PubMed database. Literature search was limited to time duration of 5 years from September 2012 to August 2017.
We analysed 521 RCTs after excluding 47 non-RCT articles from the total of 568 articles. Baseline demographic characteristics table was not reported in 45.9% of the RCTs and 26.2% of the RCTs did not report table of baseline clinical characteristics. In 38.9% of the studies, significance testing was employed to compare baseline differences between the intervention arms.
Many trials published in the reputed dental journals failed to follow the recommendations of CONSORT statement regarding reporting of baseline tables and avoiding comparison of baseline differences with significance test.
对干预组之间基线差异进行显著性检验受到了强烈谴责。本研究的目的是评估在前十大影响因子牙科期刊中使用显著性检验比较干预组之间基线特征的随机对照试验（RCT）的患病率。
在PubMed数据库中检索发表于10种高影响因子牙科期刊的随机对照试验。文献检索限于2012年9月至2017年8月的5年时间范围。
在从总共568篇文章中排除47篇非随机对照试验文章后，我们分析了521项随机对照试验。45.9%的随机对照试验未报告基线人口统计学特征表，26.2%的随机对照试验未报告基线临床特征表。在38.9%的研究中，采用显著性检验来比较干预组之间的基线差异。
许多发表在著名牙科期刊上的试验未遵循CONSORT声明中关于报告基线表格以及避免用显著性检验比较基线差异的建议。
