采用电化学方法通过酸酐对吲唑进行选择性N1-酰化反应。
Selective N1-Acylation of Indazoles with Acid Anhydrides Using an Electrochemical Approach.
作者信息
Dissanayake D M M Mevan, Vannucci Aaron K
机构信息
Department of Chemistry and Biochemistry , University of South Carolina , 541 Main Street, Columbia , South Carolina 29208 , United States.
出版信息
Org Lett. 2019 Jan 18;21(2):457-460. doi: 10.1021/acs.orglett.8b03683. Epub 2019 Jan 9.
An electrochemical synthesis method for the selective N1-acylation of indazoles has been developed. This "anion pool" approach electrochemically reduces indazole molecules generating indazole anions and H. Acid anhydrides are then introduced to the solution resulting in selective acylation of the N1-position of the indazoles. This procedure can also be applied to the acylation of benzimidazoles and indoles. The reaction can also be performed using a 9 V battery without loss of reaction efficiency.
已开发出一种用于吲唑选择性N1-酰化的电化学合成方法。这种“阴离子池”方法通过电化学还原吲唑分子生成吲唑阴离子和H。然后将酸酐引入溶液中，导致吲唑的N1位发生选择性酰化。该方法也可应用于苯并咪唑和吲哚的酰化反应。该反应也可以使用9V电池进行，而不会损失反应效率。
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