a School of Public Health , Xuzhou Medical University , Xuzhou , China.
b Department of Nutrition and Food Safety School of Public Health , Nanjing Medical University , Nanjing , China.
Int J Food Sci Nutr. 2019 Aug;70(5):570-578. doi: 10.1080/09637486.2018.1545012. Epub 2019 Jan 9.
Sulforaphane (SFN) is the major component extracted from broccoli/broccoli sprouts. It has been shown to possess anti-cancer activity. Gastric cancer is common cancer worldwide. The objective of this work was to evaluate the inhibitory effect of SFN on gastric cancer by Sonic hedgehog (Hh) Pathway. The results found that tumorsphere formation and the expression levels of gastric cancer stem cells (CSCs) markers were significantly decreased after SFN treatment. SFN also exerted inhibitory effects by suppressing proliferation and inducing apoptosis in gastric CSCs. Intriguingly, SFN inhibited the activation of Sonic Hh, a key pathway in maintaining the stemness of gastric CSCs. Upregulation of Sonic Hh pathway diminished the inhibitory effects of SFN on gastric CSCs. Collectively, these data revealed that SFN could be a potent natural compound targeting gastric CSCs via suppression of Sonic Hh pathway, which might be an promising agent for gastric cancer intervention.
萝卜硫素（SFN）是从西兰花/西兰花芽中提取的主要成分。它已被证明具有抗癌活性。胃癌是世界范围内常见的癌症。这项工作的目的是通过 Sonic hedgehog（Hh）通路评估 SFN 对胃癌的抑制作用。结果发现，SFN 处理后肿瘤球形成和胃癌干细胞（CSCs）标志物的表达水平显著降低。SFN 还通过抑制增殖和诱导胃癌 CSCs 凋亡发挥抑制作用。有趣的是，SFN 抑制了 Sonic Hh 的激活，Sonic Hh 是维持胃 CSCs 干性的关键途径。 Sonic Hh 途径的上调削弱了 SFN 对胃 CSCs 的抑制作用。总的来说，这些数据表明，SFN 可以通过抑制 Sonic Hh 通路成为一种针对胃 CSCs 的有效天然化合物，可能是一种有前途的胃癌干预药物。
