意义未明的单克隆丙种球蛋白病：基层医疗指南。

Monoclonal gammopathy of undetermined significance: A primary care guide.

机构信息

Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.

出版信息

Cleve Clin J Med. 2019 Jan;86(1):39-46. doi: 10.3949/ccjm.86a.17133.

DOI:10.3949/ccjm.86a.17133

PMID:30624183

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) is commonly diagnosed in outpatients being worked up for an array of clinical concerns. It carries a risk of progression to myeloma and other lymphoproliferative disorders that, albeit low (1% per year), warrants regular follow-up. Patients with MGUS can be risk-stratified on the basis of the amount and type of their monoclonal protein as well as whether they have an abnormal light-chain ratio. Here, we provide a guide to the diagnosis, workup, and management of MGUS.

摘要

意义未明的单克隆丙种球蛋白血症（MGUS）在因各种临床问题接受检查的门诊患者中常被诊断出来。它有进展为骨髓瘤和其他淋巴增殖性疾病的风险，尽管这种风险较低（每年 1%），但仍需要定期随访。MGUS 患者可以根据其单克隆蛋白的数量和类型以及是否存在异常轻链比来进行风险分层。在此，我们提供了一份关于 MGUS 的诊断、检查和管理的指南。