Winocur G
Department of Psychology, Trent University, Peterborough, Ontario, Canada.
Neurobiol Aging. 1988 Sep-Dec;9(5-6):487-94. doi: 10.1016/s0197-4580(88)80102-7.
This paper reports a series of experiments that assessed learning and memory performance in aged rats from a neuropsychological perspective. Relative to young adults, old rats displayed rapid rates of forgetting, increased susceptibility to interference, and poor long-term recall of specific experiences. There were no age differences on tests of short-term memory. In general, the performance of aged rats paralleled that of young rats with restricted lesions to the hippocampus, thereby supporting the conclusion that normal memory loss with age is related to progressive hippocampal dysfunction.
本文报告了一系列从神经心理学角度评估老年大鼠学习和记忆表现的实验。与年轻成年大鼠相比，老年大鼠表现出快速遗忘率、对干扰的易感性增加以及对特定经历的长期回忆能力较差。在短期记忆测试中没有年龄差异。总体而言，老年大鼠的表现与海马体有局限性损伤的年轻大鼠相似，从而支持了随着年龄增长正常记忆丧失与海马体功能逐渐衰退有关的结论。
