非酒精性脂肪性肝病患者中的硒蛋白P

Selenoprotein P in Patients with Nonalcoholic Fatty Liver Disease.

作者信息

Polyzos Stergios A, Kountouras Jannis, Mavrouli Maria, Katsinelos Panagiotis, Doulberis Michael, Gavana Elpida, Duntas Leonidas

机构信息

First Department of Pharmacology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Second Medical Clinic, Medical School, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece.

出版信息

Exp Clin Endocrinol Diabetes. 2019 Oct;127(9):598-602. doi: 10.1055/a-0811-9136. Epub 2019 Jan 9.

DOI:10.1055/a-0811-9136

PMID:30625508

Abstract

OBJECTIVE

Main aim of this study was to evaluate circulating selenoprotein P (SEPP) levels in patients with simple steatosis (SS) and nonalcoholic steatohepatitis (NASH) compared with healthy controls.

METHODS

Thirty-one patients with biopsy-proven NAFLD (15 with SS, 10 with borderline NASH, 6 with definite NASH) and 27 matched controls without NAFLD were enrolled. Serum SEPP levels and liver function tests plus biochemical parameters were measured with ELISA and standard methods, respectively. Homeostatic model of assessment - insulin resistance (HOMA-IR) was calculated.

RESULTS

SEPP levels were statistically different between groups (p-value for trend=0.043). In pairwise comparisons, SEPP was lower in definite NASH compared with controls (p=0.029), but not SS (p=0.18) or borderline NASH (p=0.35). SEPP was not different between controls, SS and borderline NASH. The unadjusted trend between the controls, SS and NASH patients remained essentially unchanged after adjustment for age, sex, log(ALT) and waist circumference, but it marginally lost significance when log(HOMA-IR) entered into the model. SEPP levels were not different between groups of different severity of steatosis, fibrosis, hepatocellular ballooning, lobular and portal inflammation.

CONCLUSIONS

Lower SEPP levels were observed in patients with definite NASH compared with controls, a finding warranting larger studies.

摘要

目的

本研究的主要目的是评估单纯性脂肪变性（SS）和非酒精性脂肪性肝炎（NASH）患者与健康对照者相比循环硒蛋白P（SEPP）水平。

方法

纳入31例经活检证实为非酒精性脂肪性肝病的患者（15例为SS，10例为临界NASH，6例为确诊NASH）和27例匹配的无NAFLD的对照者。分别采用ELISA法和标准方法检测血清SEPP水平、肝功能试验及生化参数。计算稳态模型评估-胰岛素抵抗（HOMA-IR）。

结果

各组间SEPP水平差异有统计学意义（趋势p值=0.043）。在两两比较中，确诊NASH患者的SEPP水平低于对照者（p=0.029），但SS患者（p=0.18）和临界NASH患者（p=0.35）并非如此。对照者、SS患者和临界NASH患者之间的SEPP水平无差异。在对年龄、性别、log(ALT)和腰围进行调整后，对照者、SS患者和NASH患者之间未调整的趋势基本保持不变，但当log(HOMA-IR)纳入模型时，其显著性略有下降。不同脂肪变性、纤维化、肝细胞气球样变、小叶和门管区炎症严重程度组之间的SEPP水平无差异。