Lee Jae In, Lim Se Hun, Lee Sang Eun, Kim Young Hwan, Lee Jeong Han, Lee Kun Moo, Cheong Soon Ho, Choe Young Kyun, Kim Young Jae, Shin Chee Mahn
Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, Busan, Korea.
Korean J Anesthesiol. 2009 Jun;56(6):628-633. doi: 10.4097/kjae.2009.56.6.628.
Intravenous injection of rocuronium is associated with withdrawal responses which are attributable to the pain from the injection of rocuronium. Several methods have been proposed to abolish and attenuate rocuronium-induced pain. We hypothesized priming dose of rocuronium could reduce withdrawal responses associated with administering a second large dose of rocuronium for tracheal intubation. We compared the efficacy of the priming dose technique of rocuronium with intravenous lidocaine as a pre-treatment for the prevention of withdrawal responses associated with rocuronium injection.
We recruited 150 patients aged between 18 and 60 years, ASA physical status 1 or 2, who were going to undergo elective surgery requiring general anesthesia. Patients were allocated into three groups. Group C received normal saline, Group L received lidocaine 1 mg/kg, and Group P received rocuronium 0.06 mg/kg 2 minutes before administering a second large dose of rocuronium for tracheal intubation. After the loss of consciousness, rocuronium 0.6 mg/kg was administered intravenously over 10 seconds for tracheal intubation. The withdrawal responses to the injection of rocuronium were evaluated.
The incidence of withdrawal responses associated with rocuronium injection for tracheal intubation was 56, 50, 24% in group C, group L, and group P, respectively. The incidence of withdrawal responses was lower in group P than group C and group L, but there was no difference between group L and group C.
Priming dose technique is a useful clinical method to alleviate withdrawal responses associated with rocuronium injection.
静脉注射罗库溴铵会引发退缩反应，这归因于罗库溴铵注射时的疼痛。已经提出了几种方法来消除和减轻罗库溴铵引起的疼痛。我们假设罗库溴铵的预注剂量可以减少与气管插管时给予第二大剂量罗库溴铵相关的退缩反应。我们比较了罗库溴铵预注剂量技术与静脉注射利多卡因作为预处理以预防与罗库溴铵注射相关的退缩反应的效果。
我们招募了150名年龄在18至60岁之间、美国麻醉医师协会（ASA）身体状况为1或2级、即将接受需要全身麻醉的择期手术的患者。患者被分为三组。在气管插管给予第二大剂量罗库溴铵前2分钟，C组接受生理盐水，L组接受1mg/kg利多卡因，P组接受0.06mg/kg罗库溴铵。意识消失后，静脉注射0.6mg/kg罗库溴铵，在10秒内完成气管插管。评估对罗库溴铵注射的退缩反应。
气管插管注射罗库溴铵相关的退缩反应发生率在C组、L组和P组分别为56%、50%、24%。P组的退缩反应发生率低于C组和L组，但L组和C组之间没有差异。
预注剂量技术是减轻与罗库溴铵注射相关的退缩反应的一种有用的临床方法。
