Instituto de Biotecnología de León (INBIOTEC), Parque Científico de León, Avda. Real, n°1, 24006, León, Spain.
Departamento de Biología Molecular, Universidad de León, Campus de Ponferrada, Avda. Astorga s/n, 24401, Ponferrada, Spain.
Appl Microbiol Biotechnol. 2019 Feb;103(4):1643-1658. doi: 10.1007/s00253-018-09600-2. Epub 2019 Jan 10.
The analysis of the inorganic phosphate effect over the antibiotics production is a long-distance history in the Streptomyces genus, which began almost at the same time that Michael Ende published his book entitled The Neverending Story. In some way, the unveiling of the pho regulon and its influence over the secondary metabolites production is an unfinished story, which keeps this subject as a trending topic, nowadays. Up to date, different studies have been releasing knowledge about particular areas of the pho regulon of different Streptomyces species. Nevertheless, for the first time, these knowledge drops are grouped in a review presenting a broad overview of the phosphate regulation and its impact over the secondary metabolites production in industrially relevant species. Even though the genetic response against phosphate scarcity is similar, as a whole, in different Streptomyces species, the fine-tuning is species-specific. Thus, the response regulator PhoP directly controls the secondary metabolites production in some species, whereas it regulates them in an indirect manner in other species. This information, unraveled in this review, is the result of the intensive analysis along last decade in several species of the genus that is allowing to distinguish how the phosphate response is unleashed in Streptomyces coelicolor, Streptomyces lividans, Streptomyces natalensis, Streptomyces lydicus, Streptomyces avermitilis, and Streptomyces tsukubaensis.
对无机磷酸盐对抗生素产生的影响进行分析是链霉菌属的悠久历史，几乎与迈克尔·恩德（Michael Ende）出版他的同名书籍《永远讲不完的故事》的时间同步。在某种程度上， pho 调控子的揭示及其对次生代谢产物产生的影响是一个未完成的故事，使这个主题成为当今的热门话题。迄今为止，不同的研究已经发布了关于不同链霉菌属物种的 pho 调控子特定领域的知识。然而，这些知识首次被汇集在一篇综述中，该综述全面概述了磷酸盐调控及其对工业相关物种次生代谢产物产生的影响。尽管不同链霉菌属的整体对磷酸盐缺乏的遗传反应相似，但微调是特定于物种的。因此，应答调节子 PhoP 直接控制一些物种的次生代谢产物的产生，而在其他物种中则以间接方式调节它们。这些信息是在过去十年中对该属的几个物种进行深入分析的结果，使我们能够区分磷酸盐反应在变铅青链霉菌、浅青紫链霉菌、粘质沙雷氏菌、解淀粉芽孢杆菌、阿维链霉菌和链霉菌中的释放方式。
