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在一家具备高标准护理及超声随访的中欧诊所中宫内节育器的续用率及停用原因:一项回顾性队列研究

Intrauterine device continuation rates and reasons for discontinuation in a Central European clinic with a high standard of care and ultrasound follow-up: a retrospective cohort study.

作者信息

Bachofner Marion, Blickenstorfer Kerstin, Hutmacher Juliane, Wehrle Lucia, Leeners Brigitte, Merki-Feld Gabriele

机构信息

a Department of Reproductive Endocrinology , University Hospital Zürich , Zürich , Switzerland.

出版信息

Eur J Contracept Reprod Health Care. 2018 Dec;23(6):407-414. doi: 10.1080/13625187.2018.1539164. Epub 2019 Jan 10.

DOI:10.1080/13625187.2018.1539164
PMID:30628516
Abstract

OBJECTIVES

The aims of the study were to conduct an analysis of intrauterine device (IUD)-related outcomes, including continuation rates, reasons for discontinuation, rates of dislocation and risk factors for dislocation, in a clinical setting with regular ultrasound monitoring of the IUD position.

METHODS

A retrospective chart review was carried out of all IUD insertions over a period of 5 years.

RESULTS

A total of 755 IUDs were inserted over the study period. The overall observation time was 1572 woman-years. The removal rate was highest in the first year after insertion and did not differ between devices: the 52 mg levonorgestrel-releasing intrauterine system (LNG-IUS; 18%) and third generation copper-T (Cu-T) IUDs (20%). Most removals were related to dislocation; fewer dislocations were seen with the LNG-IUS compared with the Cu-T IUDs (p< .001). More removals of the LNG-IUS were carried out because of amenorrhoea, pain and hormone-related adverse events (20% of all removals). The discontinuation rate was higher in young women (age <25 years; p< .03), demonstrating the limitations of long-acting reversible contraception in this age group. The dislocation rate for devices replaced after dislocation was 31% in women receiving a Cu-T IUD and 38% in women receiving an LNG-IUS.

CONCLUSIONS

The first year after IUD insertion is crucial with regard to discontinuation. Most removals were attributed to dislocation and affected mainly younger women. Dislocations occurred more rarely in LNG-IUS users and the rate decreased over time. We recommend follow-up within the first 6-12 months, especially in young women. Structured counselling and consideration of risk factors for dislocation may reduce removal rates for adverse events and dislocations.

摘要

目的

本研究旨在分析在对宫内节育器(IUD)位置进行定期超声监测的临床环境中,与IUD相关的结局,包括续用率、停用原因、移位率及移位的危险因素。

方法

对5年内所有IUD置入情况进行回顾性病历审查。

结果

在研究期间共置入755枚IUD。总观察时间为1572妇女年。置入后第一年取出率最高,不同类型IUD之间无差异:52mg左炔诺孕酮宫内缓释系统(LNG-IUS;18%)和第三代铜T(Cu-T)IUD(20%)。大多数取出与移位有关;与Cu-T IUD相比,LNG-IUS的移位较少(p<0.001)。因闭经、疼痛和激素相关不良事件而取出LNG-IUS的情况更多(占所有取出情况的20%)。年轻女性(年龄<25岁)的停用率更高(p<0.03),表明长效可逆避孕方法在该年龄组存在局限性。移位后更换的IUD,接受Cu-T IUD的女性移位率为31%,接受LNG-IUS的女性为38%。

结论

IUD置入后的第一年对于停用情况至关重要。大多数取出归因于移位,且主要影响年轻女性。LNG-IUS使用者的移位较少见,且移位率随时间下降。我们建议在头6至12个月内进行随访,尤其是年轻女性。结构化咨询以及考虑移位的危险因素可能会降低不良事件和移位的取出率。

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