全甲状腺切除术围手术期镁水平与低钙血症的关系。
Perioperative magnesium levels in total thyroidectomy and relationship to hypocalcemia.
机构信息
Department of Otolaryngology - Head & Neck Surgery, South Infirmary Victoria University Hospital, Cork, Ireland.
Department of Endocrinology, South Infirmary Victoria University Hospital, Cork, Ireland.
出版信息
Head Neck. 2019 Jun;41(6):1713-1718. doi: 10.1002/hed.25644. Epub 2019 Jan 10.
BACKGROUND
We have previously shown an association between hypomagnesemia and hypocalcemia after thyroidectomy. However, little is known regarding the trend in magnesium levels in the days after thyroidectomy. Our objective was to study this trend in magnesium levels after thyroidectomy.
METHODS
Retrospective review of 173 thyroidectomies with analysis of calcium and magnesium levels on postoperative day 1 (POD1) and POD2.
RESULTS
Across the whole group, there was a highly significant decline in magnesium levels between preoperative (0.87 ± 0.06 mmol/L), POD1 (0.80 ± 0.07 mmol/L), and POD2 (0.78 ± 0.08 mmol/L) (P < .0001). The magnitudes of the magnesium level declines were significantly higher, and the absolute magnesium levels on POD1 and POD2 significantly lower, in patients developing hypocalcemia (n = 69).
CONCLUSION
Magnesium levels after total thyroidectomy demonstrate a downward trajectory which persists through POD2 and is highly correlated with hypocalcemia. Further study is required to determine if magnesium replacement can alter the course of hypocalcemia in hypocalcemic patients after total thyroidectomy.
背景
我们之前已经表明，甲状腺切除术后会出现低镁血症和低钙血症。然而，关于甲状腺切除术后镁水平的趋势知之甚少。我们的目的是研究甲状腺切除术后镁水平的这种趋势。
方法
回顾性分析了 173 例甲状腺切除术，分析了术后第 1 天（POD1）和第 2 天（POD2）的钙和镁水平。
结果
在整个组中，镁水平在术前（0.87±0.06mmol/L）、术后第 1 天（0.80±0.07mmol/L）和第 2 天（0.78±0.08mmol/L）之间呈显著下降（P <0.0001）。发生低钙血症的患者（n=69）的镁水平下降幅度更大，POD1 和 POD2 的镁水平绝对值更低。
结论
甲状腺全切除术后镁水平呈下降趋势，持续至 POD2，与低钙血症高度相关。需要进一步研究以确定在甲状腺全切除术后发生低钙血症的患者中，镁替代治疗是否可以改变低钙血症的病程。
Zotero 插件