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终末期肾病合并急性外科腹痛患者:姑息治疗的机会。

Patients with End-Stage Renal Disease and Acute Surgical Abdomen: Opportunities for Palliative Care.

机构信息

Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey.

出版信息

J Palliat Med. 2019 Jun;22(6):635-643. doi: 10.1089/jpm.2018.0352. Epub 2019 Jan 10.

DOI:10.1089/jpm.2018.0352
PMID:30628847
Abstract

End-stage renal disease (ESRD) is a life-limiting condition that is often complicated by acute abdominal emergency. Palliative care (PC) has been shown to improve the quality of life in patients with serious illness and yet is underutilized. We hypothesize that ESRD patients with abdominal emergency have high unmet PC needs. To characterize the outcomes of ESRD patients with acute surgical abdomen, define PC utilization patterns, and identify areas of unmet PC needs. Retrospective study querying the National Inpatient Sample database (2009-2013). Subjects were identified using ICD-9 codes for those aged ≥50 with preexisting diagnosis of ESRD with an acute abdominal emergency diagnosis of gastrointestinal perforation, obstruction, or ischemia. Outcomes included PC rate, in-hospital mortality, discharge disposition, and intensity of care. Multivariable logistic regression analysis was used to identify predictors of PC. A total of 9363 patients met the inclusion criteria; 24% underwent surgery, 16% died in hospital, and 43% were discharged to dependent living. Among in-hospital deaths, 23% received PC. Only 4% of survivors with dependent discharge received PC. Surgical mortality was 26%. PC was less utilized in surgical patients than nonsurgical patients. PC was associated with shorter hospital stay. Predictors of PC included increasing age, severity of underlying illness, white race, teaching hospitals, and the Western region. Patients with ESRD admitted for acute abdominal emergency have high risk for mortality and functional dependence. Despite this, few receive PC and have a high utilization of nonbeneficial life support at the end of life.

摘要

终末期肾病(ESRD)是一种生命有限的疾病,常伴有急性腹部急症。姑息治疗(PC)已被证明可改善重病患者的生活质量,但利用率仍然较低。我们假设,患有急性腹部急症的 ESRD 患者有很高的未满足的 PC 需求。 描述患有急性外科腹部急症的 ESRD 患者的结局,定义 PC 使用模式,并确定未满足的 PC 需求领域。 这是一项回顾性研究,在 2009 年至 2013 年期间查询了国家住院患者样本数据库。 受试者使用 ICD-9 代码确定,这些代码适用于年龄≥50 岁、有 ESRD 既往诊断、伴有胃肠道穿孔、梗阻或缺血的急性腹部急症诊断的患者。 结局包括 PC 率、院内死亡率、出院去向和护理强度。多变量逻辑回归分析用于确定 PC 的预测因素。 共有 9363 名患者符合纳入标准;24%接受了手术,16%在医院死亡,43%出院到依赖生活。在院内死亡患者中,23%接受了 PC。只有 4%有依赖出院的幸存者接受了 PC。手术死亡率为 26%。手术患者的 PC 使用率低于非手术患者。PC 与住院时间缩短有关。PC 的预测因素包括年龄增长、基础疾病严重程度、白种人、教学医院和西部地区。 因急性腹部急症入院的 ESRD 患者死亡率和功能依赖性高。尽管如此,很少有患者接受 PC,并且在生命末期非有益生命支持的利用率很高。

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