Tas Faruk, Erturk Kayhan
From the Department of Medical Oncology, Institute of Oncology, University of Istanbul, Istanbul, Turkey.
Ann Plast Surg. 2019 Apr;82(4):407-410. doi: 10.1097/SAP.0000000000001695.
Most head and neck melanomas occur on the face, with the cheek being the most frequently affected site. So far, small numbers of researches on cheek melanomas have yielded insufficient and controversial results. In this trial, we aimed to define the histopathological and clinical features specific to cheek melanomas and to compare them with other head and neck melanomas by using a large group of patients from a single tertiary center.
A total of 98 cheek melanomas and 183 other (noncheek) head and neck melanoma cases were analyzed retrospectively.
The median age was 62 years and malar/zygomatic was the mostly affected site (78.6%). The cheek melanomas developed more frequently in females (61.2%) and most of them were associated with lentigo maligna histopathological subtype (49.2%) and early-stage disease (stage 0-II) (77.6%). The cheek melanomas were found more significantly associated with older patients (P = 0.05), females (P = 0.0001), lentigo maligna subtype (P = 0.0001), lower vertical growth phase (P = 0.03), and early-stage of disease (P = 0.0001) compared with other lesions that developed other sites. Furthermore, they were associated with lower relapse rates (18.6% vs 39.5%, P = 0.0001) and the 5-year recurrence-free survival rate of cheek melanomas was 80% (P = 0.002). Moreover, the 5-year overall survival rate of cheek melanomas was 62%, and they were found to be associated with a favorable overall survival (P = 0.004).
Cheek melanomas are associated with lower relapse rates and favorable outcomes compared with other (noncheek) head and neck melanomas.
大多数头颈部黑色素瘤发生在面部，其中脸颊是最常受累的部位。到目前为止，关于脸颊黑色素瘤的研究较少，结果不充分且存在争议。在本试验中，我们旨在通过一个单一三级中心的大量患者来确定脸颊黑色素瘤特有的组织病理学和临床特征，并将其与其他头颈部黑色素瘤进行比较。
回顾性分析了98例脸颊黑色素瘤和183例其他（非脸颊）头颈部黑色素瘤病例。
中位年龄为62岁，颊部/颧骨是最常受累部位（78.6%）。脸颊黑色素瘤在女性中更常见（61.2%），大多数与恶性雀斑样痣组织病理学亚型相关（49.2%），且多为早期疾病（0-II期）（77.6%）。与发生在其他部位的病变相比，脸颊黑色素瘤与老年患者（P = 0.05）、女性（P = 0.0001）、恶性雀斑样痣亚型（P = 0.0001）、较低的垂直生长期（P = 0.03）和疾病早期（P = 0.0001）显著相关。此外，它们的复发率较低（18.6%对39.5%，P = 0.0001），脸颊黑色素瘤的5年无复发生存率为80%（P = 0.002）。此外，脸颊黑色素瘤的5年总生存率为62%，且发现其总生存率良好（P = 0.004）。
与其他（非脸颊）头颈部黑色素瘤相比，脸颊黑色素瘤的复发率较低，预后良好。
