等容条件可实现无渗透保护剂的胰岛在深低温下的保存。
Isochoric conditions enable high subfreezing temperature pancreatic islet preservation without osmotic cryoprotective agents.
机构信息
Department of Mechanical Engineering, University of California, Berkeley, Berkeley, CA, 94720, USA.
Department of Mechanical Engineering, University of California, Berkeley, Berkeley, CA, 94720, USA; Department of Endocrinology and Metabolism, Luoyang Central Hospital Affliated to Zhengzhou University, Luoyang, 471009, PR China.
出版信息
Cryobiology. 2019 Feb;86:130-133. doi: 10.1016/j.cryobiol.2019.01.003. Epub 2019 Jan 7.
While biological systems are typically studied under isobaric (constant pressure) conditions, recent reports on the bio-thermodynamics of isochoric (constant volume) systems point to their potential for subfreezing-temperature preservation of biological matter. This preliminary study, in which we report that pancreatic islets can survive multi-day preservation at high subfreezing temperatures in an isochoric chamber without osmotic cryoprotective agents (CPA), highlights the potential of isochoric cryopreservation in an application of clinical value.
虽然生物系统通常在等压（恒压）条件下进行研究，但最近关于等容（恒容）系统生物热力学的报告指出，它们有可能实现生物物质在亚低温下的保存。在这项初步研究中，我们报告了胰岛可以在等容室中在高亚低温下存活多天而无需渗透冷冻保护剂（CPA），这突出了等容冷冻保存在具有临床价值的应用中的潜力。
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