Center for Translational Medicine, Jane and Leonard Korman Lung Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Center for Translational Medicine, Jane and Leonard Korman Lung Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Arch Biochem Biophys. 2019 Mar 15;663:109-119. doi: 10.1016/j.abb.2019.01.002. Epub 2019 Jan 8.
Mitochondria are important for airway smooth muscle physiology due to their diverse yet interconnected roles in calcium handling, redox regulation, and cellular bioenergetics. Increasing evidence indicates that mitochondria dysfunction is intimately associated with airway diseases such as asthma, IPF and COPD. In these pathological conditions, increased mitochondrial ROS, altered bioenergetics profiles, and calcium mishandling contribute collectively to changes in cellular signaling, gene expression, and ultimately changes in airway smooth muscle contractile/proliferative properties. Therefore, understanding the basic features of airway smooth muscle mitochondria and their functional contribution to airway biology and pathology are key to developing novel therapeutics for airway diseases. This review summarizes the recent findings of airway smooth muscle mitochondria focusing on calcium homeostasis and redox regulation, two key determinants of physiological and pathological functions of airway smooth muscle.
线粒体在气道平滑肌生理学中具有重要作用，因为它们在钙处理、氧化还原调节和细胞生物能量学方面具有多样化但相互关联的作用。越来越多的证据表明，线粒体功能障碍与哮喘、特发性肺纤维化和 COPD 等气道疾病密切相关。在这些病理条件下，增加的线粒体 ROS、改变的生物能量谱和钙处理不当共同导致细胞信号转导、基因表达的变化，并最终导致气道平滑肌收缩/增殖特性的变化。因此，了解气道平滑肌线粒体的基本特征及其对气道生物学和病理学的功能贡献是开发气道疾病新疗法的关键。这篇综述总结了气道平滑肌线粒体的最新发现，重点关注钙稳态和氧化还原调节，这是气道平滑肌生理和病理功能的两个关键决定因素。
