Oncodermatology and Trichology Clinic, National University of Mexico, Mexico City, Mexico.
Dermatology Department, Dr. Manuel Gea Gonzalez General Hospital, Mexico City, Mexico.
J Am Acad Dermatol. 2023 Oct;89(4):758-763. doi: 10.1016/j.jaad.2018.12.047. Epub 2019 Jan 8.
Alopecia areata (AA) is a common form of nonscarring hair loss. It is believed to be a consequence of an immune-mediated stimulus, probably involving autoreactive T cells against antigens present in the hair follicle. The exact antigen is still unknown; however, some authors have proposed that melanogenesis-associated molecules might trigger autoimmunity. Although transient white hair regrowth is a common and well-known situation in AA, there are other types of white hair phenomena in this context, including permanent white hair regrowth, sparing of white hair in a patchy pattern, or sparing in a diffuse pattern, giving the appearance of the so-called overnight graying phenomena or canitis subita. In this review, we aim to describe the different clinical aspects of white hair in AA, as well as the proposed pathophysiologic mechanisms involved in this phenomena.
斑秃（AA）是一种常见的非瘢痕性脱发。据信，它是一种免疫介导的刺激的结果，可能涉及针对毛囊中存在的自身抗原的自身反应性 T 细胞。确切的抗原仍然未知；然而，一些作者提出，黑色素生成相关分子可能引发自身免疫。尽管暂时性白发再生是 AA 中常见且众所周知的情况，但在这种情况下还有其他类型的白发现象，包括永久性白发再生、斑片状或弥漫性保留白发，表现为所谓的一夜之间白发或突发性白发。在这篇综述中，我们旨在描述 AA 中白发的不同临床方面，以及涉及这种现象的拟议病理生理机制。
