Yang Min, Xin Ying
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
J Pediatr Adolesc Gynecol. 2019 Jun;32(3):330-333. doi: 10.1016/j.jpag.2019.01.001. Epub 2019 Jan 7.
Yolk sac tumors (YSTs) are rare malignancies that originate from germ cells and rarely present with endocrine symptoms. We report a case of a 13-year-old girl with a YST manifesting as virilization.
A 13-year-old girl was diagnosed with a YST with endocrine symptoms because of Leydig cells in the stroma, which were identified using hematoxylin and eosin staining and immunohistochemistry.
This case suggests that clinicians should consider the possibility of YST when encountering patients with symptoms of virilization. When a YST is found to have endocrine function, a functioning stroma could present. Immunohistochemistry is useful for identifying stromal cells and performing a differential diagnosis.
卵黄囊瘤（YSTs）是起源于生殖细胞的罕见恶性肿瘤，很少出现内分泌症状。我们报告一例13岁女孩的卵黄囊瘤表现为男性化。
一名13岁女孩因间质中的睾丸间质细胞被诊断为具有内分泌症状的卵黄囊瘤，这些细胞通过苏木精和伊红染色及免疫组织化学得以鉴定。
该病例提示临床医生在遇到有男性化症状的患者时应考虑卵黄囊瘤的可能性。当发现卵黄囊瘤具有内分泌功能时，可能存在有功能的间质。免疫组织化学有助于识别间质细胞并进行鉴别诊断。
