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钝性胸主动脉损伤:血管内修复现在是标准治疗方法。

Blunt Thoracic Aortic Injury: Endovascular Repair Is Now the Standard.

机构信息

R Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, MD.

R Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, MD.

出版信息

J Am Coll Surg. 2019 Apr;228(4):605-610. doi: 10.1016/j.jamcollsurg.2018.12.022. Epub 2019 Jan 8.

Abstract

BACKGROUND

Incidence and treatment of blunt thoracic aortic injury (BTAI) has evolved, likely from improved imaging and emergence of endovascular techniques; however, multicenter data demonstrating this are lacking. We examined trends in incidence, management, and outcomes in BTAI.

STUDY DESIGN

The American College of Surgeons National Trauma Databank (2003 to 2013) was used to identify adults with BTAI. Management was categorized as nonoperative repair, open aortic repair (OAR), or thoracic endovascular repair (TEVAR). Outcomes included demographics, management, and outcomes.

RESULTS

There were 3,774 patients. Median age was 46.0 years (interquartile range [IQR] 29.3, 62.0 years), with 70.8% males, and median Injury Severity Score (ISS) of 34.0 (IQR 26.0, 45.0). The number of BTAIs diagnosed over the decade increased 196.8% (p < 0.001), median ISS decreased from 38 to 33 (p < 0.001), and significantly more patients were treated at a level I trauma center (p < 0.001). After FDA approval of TEVAR devices, there was a significant increase in endovascular repair overall (1.0% to 30.6%, p < 0.001) and in those treated operatively (0.0% to 94.9%, p < 0.001), with a marked decrease in OAR. Use of TEVAR was associated with significantly reduced median ICU LOS (9.0 vs 12.0 days, p = 0.048) and mortality (9.3% vs 16.6%; p = 0.015) compared with OAR. In modern BTAI care, TEVAR has nearly completely replaced OAR.

CONCLUSIONS

The diagnosis of BTAI has increased, likely due to more sensitive imaging. Nearly 70% of patients get nonoperative care. Treatment with TEVAR improves outcomes relative to OAR. Part of the proportional increase in TEVAR use may represent overtreatment of lower grade BTAI amenable to medical management, and warrants further investigation.

摘要

背景

钝性胸主动脉损伤(BTAI)的发生率和治疗方法已经发生了变化,可能是由于影像学的改善和血管内技术的出现;然而,缺乏多中心数据来证明这一点。我们研究了 BTAI 发生率、治疗方法和结果的趋势。

研究设计

美国外科医师学会国家创伤数据库(2003 年至 2013 年)用于确定 BTAI 的成年人。治疗方法分为非手术修复、开放主动脉修复(OAR)或胸主动脉腔内修复(TEVAR)。结果包括人口统计学、治疗方法和结果。

结果

共有 3774 例患者。中位年龄为 46.0 岁(四分位距[IQR] 29.3,62.0 岁),男性占 70.8%,损伤严重程度评分(ISS)中位数为 34.0(IQR 26.0,45.0)。十年间,BTAI 的诊断数量增加了 196.8%(p < 0.001),ISS 中位数从 38 降至 33(p < 0.001),且更多患者在 I 级创伤中心接受治疗(p < 0.001)。在 FDA 批准 TEVAR 设备后,整体血管内修复的比例显著增加(1.0%至 30.6%,p < 0.001),接受手术治疗的比例也显著增加(0.0%至 94.9%,p < 0.001),而 OAR 的比例显著下降。与 OAR 相比,TEVAR 的使用与 ICU 住院时间(9.0 天与 12.0 天,p = 0.048)和死亡率(9.3%与 16.6%;p = 0.015)显著降低相关。在现代 BTAI 治疗中,TEVAR 几乎完全取代了 OAR。

结论

BTAI 的诊断有所增加,可能是由于更敏感的影像学检查。近 70%的患者接受非手术治疗。与 OAR 相比,TEVAR 治疗可改善预后。TEVAR 使用比例的增加部分可能代表对更适合药物治疗的低级别 BTAI 的过度治疗,这需要进一步研究。

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