新型止血黏附粉治疗难治性上消化道出血的疗效：一项初步研究。
Efficacy of a novel hemostatic adhesive powder in patients with refractory upper gastrointestinal bleeding: a pilot study.
机构信息
Digestive Disease Center, Department of Internal Medicine, Inha University School of Medicine, Incheon, Republic of Korea.
Digestive Disease Center, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea.
出版信息
Endoscopy. 2019 May;51(5):458-462. doi: 10.1055/a-0809-5276. Epub 2019 Jan 10.
BACKGROUND
A new hemostatic adhesive powder (UI-EWD) has been developed to reduce the high re-bleeding rates associated with the currently available hemostatic powders. The current study aimed to assess the efficacy of UI-EWD as a salvage therapy for the treatment of refractory upper gastrointestinal bleeding (UGIB).
METHODS
A total of 17 consecutive patients who had failed to achieve hemostasis with conventional endoscopic procedures and had undergone treatment with UI-EWD for endoscopic hemostasis in refractory UGIB were prospectively enrolled in the study. We evaluated the success rate of initial hemostasis and rate of re-bleeding within 30 days.
RESULTS
All patients underwent successful UI-EWD application at the bleeding site. Initial hemostasis occurred in 16/17 patients (94 %). Re-bleeding within 30 days occurred in 3/16 patients (19 %) who had achieved initial hemostasis. In the second-look endoscopy after 24 hours, hydrogel from UI-EWD was found attached at the bleeding site in 11/16 patients (69 %).
CONCLUSION
UI-EWD has a high success rate for initial hemostasis in refractory UGIB and shows promising results in the prevention of re-bleeding.
背景
一种新型止血黏附粉（UI-EWD）已被开发出来，以降低目前可用的止血粉相关的高再出血率。本研究旨在评估 UI-EWD 作为治疗难治性上消化道出血（UGIB）的挽救性治疗的疗效。
方法
本研究前瞻性纳入了 17 例连续接受常规内镜治疗未能止血且接受 UI-EWD 内镜止血治疗的难治性 UGIB 患者。我们评估了初始止血的成功率和 30 天内再出血的发生率。
结果
所有患者均在出血部位成功应用 UI-EWD。16/17 例患者（94%）达到初始止血。在 16 例达到初始止血的患者中，有 3 例（19%）在 30 天内再次出血。在 24 小时后的第二次内镜检查中，11/16 例（69%）患者的出血部位发现 UI-EWD 的水凝胶附着。
结论
UI-EWD 治疗难治性 UGIB 的初始止血成功率高，在预防再出血方面显示出良好的效果。
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