Phoebe Putney Memorial Hospital, Albany, GA, USA.
SWGA Clinical Campus, University of Georgia College of Pharmacy, Albany, GA, USA.
J Pharm Pract. 2020 Aug;33(4):477-480. doi: 10.1177/0897190018822561. Epub 2019 Jan 10.
To describe the potential role of phenobarbital as appropriate therapy in the treatment and prevention of alcohol withdrawal syndrome (AWS) among medically cleared psychiatric inpatients.
This was a single-center, retrospective, observational study of adult patients admitted to the psychiatric unit and administered phenobarbital for the treatment or prevention of AWS. Changes in vital signs and signs and symptoms of AWS were observed to assess the safety and efficacy of phenobarbital. The primary outcome was safety of phenobarbital for AWS as measured by change in the respiratory rate (RR).
A total of 122 patients were included in the study. There were no significant changes in RR among patients who received phenobarbital for AWS. Significant reductions in blood pressure and heart rate were observed. Of patients with documented signs and symptoms of AWS upon admission, 94% had improvement in the signs and symptoms during phenobarbital therapy. Approximately 12% of patients had documented sedation or altered mental status during phenobarbital therapy. No patients required transfer to a medical or critical care unit.
Phenobarbital was safe, not leading to severe adverse effects or requiring a higher level of care, and efficacious for the prevention and treatment of AWS in this cohort of psychiatric inpatients.
描述苯巴比妥作为适当治疗药物在清除医学因素的住院精神科患者的酒精戒断综合征（AWS）治疗和预防中的潜在作用。
这是一项单中心、回顾性、观察性研究，纳入了接受苯巴比妥治疗或预防 AWS 的成年精神科住院患者。观察生命体征和 AWS 的体征和症状的变化，以评估苯巴比妥的安全性和疗效。主要结局是苯巴比妥治疗 AWS 的安全性，通过呼吸频率（RR）的变化来衡量。
共有 122 名患者纳入研究。接受苯巴比妥治疗 AWS 的患者 RR 无显著变化。观察到血压和心率显著降低。入院时有记录 AWS 体征和症状的患者中，94%在苯巴比妥治疗期间体征和症状得到改善。大约 12%的患者在苯巴比妥治疗期间有记录的镇静或意识状态改变。无患者需要转至医疗或重症监护病房。
在该队列的住院精神科患者中，苯巴比妥安全，不会导致严重不良事件或需要更高水平的护理，并且对 AWS 的预防和治疗有效。
