Bicknell E J, Van't Hoff W
Department of Endocrinology and Diabetes Mellitus, North Staffordshire Royal Infirmary, Stoke-on-Trent, UK.
Ann Clin Biochem. 1988 Jul;25 ( Pt 4):367-72. doi: 10.1177/000456328802500407.
We present the results obtained using a 1-84 human parathyroid hormone (PTH) assay in patients with abnormal calcium metabolism. A normal range was established in a series of healthy volunteers. Patients with surgically proven hyperparathyroidism (HPT) showed increased PTH levels which were separate from the normal range. Patients with probable hyperparathyroidism and milder hypercalcaemia showed a raised median PTH level but the range overlapped with normal. Patients with hypercalcaemia of malignancy showed reduced PTH levels and these patients were readily differentiated from those with probable and proven HPT by the use of the assay. In patients with chronic renal failure PTH values ranged from normal to high, the PTH concentration was found to be correlated with plasma alkaline phosphatase, but not with plasma creatinine.
我们展示了在钙代谢异常患者中使用1-84人甲状旁腺激素（PTH）检测法所获得的结果。在一系列健康志愿者中确定了正常范围。经手术证实的甲状旁腺功能亢进症（HPT）患者的PTH水平升高，且与正常范围分离。可能患有甲状旁腺功能亢进症且血钙轻度升高的患者，其PTH水平中位数升高，但范围与正常范围重叠。恶性肿瘤高钙血症患者的PTH水平降低，通过该检测法可轻易将这些患者与可能患有及已证实患有HPT的患者区分开来。慢性肾衰竭患者的PTH值范围从正常到升高，发现PTH浓度与血浆碱性磷酸酶相关，但与血浆肌酐无关。
