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原发性干燥综合征患者外周血中 FoxP3+CXCR5+CD4+T 细胞频率增加。

FoxP3 CXCR5 CD4 T cell frequencies are increased in peripheral blood of patients with primary Sjögren's syndrome.

机构信息

Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway.

出版信息

Clin Exp Immunol. 2019 Mar;195(3):305-309. doi: 10.1111/cei.13244. Epub 2019 Jan 10.

DOI:10.1111/cei.13244
PMID:30632148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6378374/
Abstract

We recently explored the expression of CXCR5 on T and B cells from peripheral blood of patients with primary Sjögren's syndrome (SS). Here we investigated the frequency of CD25 FoxP3 CD4 regulatory T cells (T ) among CXCR5 CD4 follicular cells in the same cohort of patients. We confirm that the frequency of T among follicular T cells is increased in SS patients and also provide novel data showing an increased frequency of PD-1 expressing cells among CXCR5 FoxP3 CD4 T cells.

摘要

我们最近研究了原发性干燥综合征（SS）患者外周血 T 细胞和 B 细胞中 CXCR5 的表达。在此，我们在同一批患者中研究了 CXCR5+CD4 滤泡细胞中 CD25 FoxP3+CD4 调节性 T 细胞（Treg）的频率。我们证实 SS 患者滤泡性 T 细胞中 Treg 的频率增加，并提供了新的数据，显示 CXCR5+FoxP3+CD4 T 细胞中 PD-1 表达细胞的频率增加。

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1
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Clin Exp Immunol. 2019 Mar;195(3):305-309. doi: 10.1111/cei.13244. Epub 2019 Jan 10.
2
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本文引用的文献

1
Is the T Follicular Regulatory:Follicular Helper T Cell Ratio in Blood a Biomarker for Ectopic Lymphoid Structure Formation in Sjögren's Syndrome? Comment on the Article by Fonseca et al.血液中滤泡调节性T细胞与滤泡辅助性T细胞的比例是干燥综合征异位淋巴结构形成的生物标志物吗？对Fonseca等人文章的评论
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2
Diminished CXCR5 expression in peripheral blood of patients with Sjögren's syndrome may relate to both genotype and salivary gland homing.干燥综合征患者外周血中 CXCR5 表达降低可能与基因型和唾液腺归巢均相关。
Clin Exp Immunol. 2018 Jun;192(3):259-270. doi: 10.1111/cei.13118. Epub 2018 Mar 24.
3
The Ratio of Blood T Follicular Regulatory Cells to T Follicular Helper Cells Marks Ectopic Lymphoid Structure Formation While Activated Follicular Helper T Cells Indicate Disease Activity in Primary Sjögren's Syndrome.血液滤泡调节性 T 细胞与滤泡辅助性 T 细胞的比值标志着原发性干燥综合征中异位淋巴样结构的形成，而活化的滤泡辅助性 T 细胞则提示疾病的活动度。
Arthritis Rheumatol. 2018 May;70(5):774-784. doi: 10.1002/art.40424. Epub 2018 Mar 25.
4
Human blood T cells are indicators of ongoing humoral activity not fully licensed with suppressive function.人类血液中的T细胞是正在进行的体液活动的指标，其抑制功能尚未完全具备。
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Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.循环前体 CCR7(lo)PD-1(hi)CXCR5⁺CD4⁺T 细胞表明滤泡辅助性 T 细胞（Tfh 细胞）活性，并在再次暴露抗原时促进抗体应答。
Immunity. 2013 Oct 17;39(4):770-81. doi: 10.1016/j.immuni.2013.09.007.
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Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses.人类循环 PD-1+CXCR3-CXCR5+记忆性滤泡辅助 T 细胞具有高度功能性，与广泛中和 HIV 抗体反应相关。
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Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.表达FoxP3转录因子的人CD4+ T细胞的功能划分与分化动力学
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