Grubbs 催化剂在α-重氮酯的分子内碳烯 C(sp)-H 插入反应中的应用。
Grubbs catalysts in intramolecular carbene C(sp)-H insertion reactions from α-diazoesters.
机构信息
Laboratori de Química Orgànica, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain.
Departamento de Química Orgánica I and Centro de Innovación en Química Avanzada (ORFEO-CINQA), Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.
出版信息
Chem Commun (Camb). 2019 Jan 25;55(8):1160-1163. doi: 10.1039/c8cc09089k. Epub 2019 Jan 11.
Grubbs catalysts are described as a useful alternative to promote intramolecular carbene C-H insertion from α-diazoesters. Moreover, no competition arises from the possible metathesis reactions on substrates bearing alkene and alkyne moieties. DFT calculations were also carried out to gain insight into the reaction mechanism involved in these transformations.
Grubbs 催化剂被描述为一种促进α-重氮酯分子内卡宾 C-H 插入的有用替代品。此外，在含有烯烃和炔烃部分的底物上，不会发生可能的复分解反应。还进行了 DFT 计算，以深入了解这些转化涉及的反应机制。
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