硼酸酯键交联多糖缀合物用于 pH 响应型和靶向药物递送。
Boronate-crosslinked polysaccharide conjugates for pH-responsive and targeted drug delivery.
机构信息
College of Science, Inner Mongolia Agricultural University, Hohhot 010018, P. R. China and Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China.
Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China.
出版信息
Chem Commun (Camb). 2019 Jan 25;55(8):1164-1167. doi: 10.1039/c8cc09956a. Epub 2019 Jan 11.
A pH-responsive and targeted polysaccharide conjugate was fabricated from the boronate linkage of N-(2-aminoethyl)-gluconamide-grafted hyaluronic acid with anticancer drug bortezomib, which could exhibit targeted drug release behaviors at acidic pH and possess lower cytotoxicity and a higher inhibition effect toward cancer cells.
一种 pH 响应型和靶向性多糖缀合物是通过硼酸酯键将接枝有 N-(2-氨乙基)-葡糖酰胺的透明质酸与抗癌药物硼替佐米偶联而成，它可以在酸性 pH 下表现出靶向药物释放行为，并且对癌细胞的细胞毒性更低，抑制效果更高。
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