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大气污染与北京地区湿疹和皮炎患者的门诊就诊率:一项时间分层病例交叉研究。

Ambient air pollution and the hospital outpatient visits for eczema and dermatitis in Beijing: a time-stratified case-crossover analysis.

机构信息

Department of Occupational and Environmental Health, School of Public Health, Peking University, Xueyuan Road 38, Haidian District, Beijing 100191, China.

出版信息

Environ Sci Process Impacts. 2019 Jan 23;21(1):163-173. doi: 10.1039/c8em00494c.

Abstract

BACKGROUND

Eczema and dermatitis are a group of common skin conditions with multiple risk factors. Evidence of the effects of air pollutants on eczema and dermatitis remains limited. This study aimed to investigate the effects of short-term exposure to air pollution on eczema and dermatitis in Beijing.

METHODS

A time-stratified case-crossover design was used to assess the associations between short-term changes in air pollution and the hospital outpatient visits for eczema and dermatitis in Beijing.

RESULTS

A total of 157 595 outpatient visits for eczema and dermatitis were recorded from April 1, 2012 to April 30, 2014. All pollutants showed significant positive associations with the number of outpatient visits for eczema and dermatitis on lag 0 (the current day). Per IQR increase in PM2.5, PM10, NO2 and SO2 was associated with 3.81% (95% CI: 2.92-4.7%), 3.18% (95% CI: 2.39-3.97%), 5.43% (95% CI: 4.43-6.43%) and 5.57% (95% CI: 4.55-6.58%) increases in outpatient visits for eczema and dermatitis on lag 0. Associations of air pollutants with eczema and dermatitis outpatient visits varied with the seasons and were stronger among older people and females. Also, an association of consecutive days' high concentration pollution with increased outpatient visits was observed.

CONCLUSIONS

Exposure to air pollution increases the exacerbation of eczema and dermatitis and stronger positive associations between air pollutants and outpatient visits for eczema and dermatitis were found among the aged, females and when high concentration air pollution occurs continuously.

摘要

背景

湿疹和皮炎是一组常见的皮肤疾病,具有多种危险因素。有关空气污染物对湿疹和皮炎影响的证据仍然有限。本研究旨在调查北京地区短期暴露于空气污染对湿疹和皮炎的影响。

方法

采用时间分层病例交叉设计,评估空气污染短期变化与北京湿疹和皮炎患者门诊就诊次数之间的关系。

结果

共记录了 2012 年 4 月 1 日至 2014 年 4 月 30 日期间 157595 例湿疹和皮炎的门诊就诊记录。所有污染物与湿疹和皮炎的门诊就诊次数均呈显著正相关(滞后 0 天)。与 PM2.5、PM10、NO2 和 SO2 的 IQR 每增加 1μg/m3,分别与滞后 0 天就诊次数增加 3.81%(95%CI:2.92-4.7%)、3.18%(95%CI:2.39-3.97%)、5.43%(95%CI:4.43-6.43%)和 5.57%(95%CI:4.55-6.58%)相关。空气污染物与湿疹和皮炎门诊就诊次数的相关性因季节而异,在老年人和女性中更强。此外,还观察到连续高浓度污染日与门诊就诊次数增加之间存在关联。

结论

暴露于空气污染会加重湿疹和皮炎的恶化,并且在老年人、女性以及高浓度空气污染连续出现时,空气污染物与湿疹和皮炎门诊就诊次数之间存在更强的正相关关系。

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